2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPARα/γ agonist 2

PPARα/γ agonist 2 是一种具有口服活性的 PPARα 完全激动剂和 PPARγ 部分激动剂。PPARα/γ agonist 2 激活 PPARα 和 PPARγ，EC50 值分别为 0.95 μM 和 0.91 μM。PPARα/γ agonist 2 也是 PTP1B 抑制剂。 PPARα/γ 激动剂 2 是一种抗糖尿病试剂。

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PPARα/γ agonist 2 Chemical Structure

PPARα/γ agonist 2 Chemical Structure

CAS No. : 2213365-56-9

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PPARα/γ agonist 2 相关抗体

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent[1].

IC50 & Target[1]

PPARα

0.95 μM (EC50)

PPARγ

0.91 μM (EC50)

体外研究
(In Vitro)

PPARα/γ agonist 2 (化合物 10) 有效抑制 PTP1B，IC50 为 13.2 μM (动力学测定)[1]。
PPARα/γ agonist 2 (25 μM，30 分钟) 在 C2C12 细胞中以胰岛素-非依赖性机制增强葡萄糖的摄取，并且比 UK5099 (HY-15475) 更有效[1]。
PPARα/γ agonist 2 (25 μM，30 分钟) 降低 C2C12 细胞中的线粒体膜电位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PPARα/γ agonist 2 相关抗体:
体内研究
(In Vivo)

PPARα/γ agonist 2 (化合物 10) (25 and 50 mg/kg, p.o.) 降低 STZ 诱导的糖尿病小鼠的血糖水平和脂质含量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: STZ-induced diabetic mice[1]
Dosage: 25 and 50 mg/kg
Administration: p.o.
Result: Reduced the levels of TC, HDL, LDL-C, VLDL-C, and TG.
Brought diabetes-induced hyperlipidemia back to normal.
分子量

368.42

Formula

C25H20O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPARα/γ agonist 2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARα/γ agonist 22213365-56-9PPARPeroxisome proliferator-activated receptorsSTZdiabeticblood glucoselipidMMPC2C12 cellInhibitorinhibitorinhibit

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目录号：
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