2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Procaterol

Procaterol  (Synonyms: 丙卡特罗; 美喘清; 丙卡特罗气雾剂)

目录号: HY-114732
产品使用指南

摩尔计算器

Procaterol 是一种可口服的选择性 β2 adrenergic receptor 激动剂。Procaterol可通过环磷酸腺苷依赖性机制直接抑制嗜酸性粒细胞迁移和 BEAS-2B 细胞释放嗜酸性粒细胞趋化活性因子。Procaterol对大鼠的支气管扩张作用和代谢作用存在较大的剂量差，可用于运动员哮喘研究。

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Procaterol Chemical Structure

Procaterol Chemical Structure

CAS No. : 72332-33-3

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Procaterol 相关抗体

Top Publications Citing Use of Products

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes[1].

IC50 & Target[1]

β2 adrenoceptor

 

体外研究
(In Vitro)

Procatero (10-1000 ng/mL, 12, 24, 48 h, BEAS-2B) 通过环 AMP 依赖性机制直接抑制嗜酸性粒细胞迁移和 BEAS-2B 细胞中嗜酸性粒细胞趋化因子的释放[3]。
Procaterol (10-1000 ng/mL, 12, 24, 48 h, BEAS-2B) 剂量依赖性抑制 BEAS-2B 细胞单层对 IL-1b 和 TNF-a 反应的 RANTES 释放, 在 IL-1b 作用下增强 GM-CSF mRNA 的表达[3]。
Procaterol (0.1 μM, 72 h, Human tracheal surface epithelial cells) 可降低鼻病毒滴度和 RNA、细胞因子浓度、鼻病毒感染易感性、14 型鼻病毒受体细胞间粘附分子-1 (ICAM-1) 的表达以及鼻病毒 RNA 进入细胞质的细胞内酸性内体的数量[4]。
Procaterol (10 nM, one time, Lung ephelial cells) 通过 cAMP 以剂量依赖的方式增加 ciliary bend amplitude (CBA) 和 ciliary beating frequency (CBF)[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Procaterol 相关抗体:

Cell Migration Assay [3]

Cell Line: eosinophil
Concentration: 10, 100, 1000 ng/mL
Incubation Time: 24 h
Result: Attenuated the eosinophil migratory response in a dose-dependent.
体内研究
(In Vivo)

Procaterol (0.03-1 mg/kg, inhalation 3 times a day, 14 days) 大鼠腓肠肌的重量或体重增加没有明显变化[1]。
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) 显著地增加了提肛肌的重量，有合成代谢作用[1]。
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) 增加腹侧前列腺重量与药物对组织中b2肾上腺素受体的刺激有关[1]。
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) 的支气管扩张作用与合成代谢作用的剂量差异大于 30 倍，小于100 倍[2]。
Procaterol (0.1, 1, 10 mg/kg, orally, before ovalbumin (HY-W250978) (OVA) inhalation) 吸入不会增强气道高反应性、气道壁炎症或气道壁增厚，并能减少嗜酸性粒细胞的数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old rats were castrated on Day – 5, except for a normal group of 6 rats[1]
Dosage: 0.03, 0.1, 0.3, 1 mg/mL
Administration: in-halation 3 times a day (09 : 00, 12 : 00, 16 : 00) for 14 days from Day 0 to Day 13.
Result: No significant changed in weight or body weight gain in rat gastrocnemius muscle. Significantly increased the weight of the levator ani muscle. Increasd in ventral prostate weight.
Animal Model: Mice immunized with ovalbumin (HY-W250978) (OVA, inhalation of 20 mg/mL OVA for 10 minutes every other day, total 7 times) + alum[2]
Dosage: 0.1, 1, 10 mg/kg
Administration: orally, before ovalbumin (HY-W250978) (OVA) inhalation
Result: Inhalation did not enhance airway hyperresponsiveness, airway wall inflammation, or airway wall thickening after OVA inhalation.
Reduced the number of eosinophils in BALF mice.
分子量

290.36

Formula

C16H22N2O3
CAS 号
中文名称

丙卡特罗
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Procaterol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procaterol72332-33-3丙卡特罗Adrenergic ReceptorBeta Receptorselectiveagonistin-haledBEAS-2Basthmacastrated ratInhibitorinhibitorinhibit

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