2. Immunology/Inflammation Anti-infection
  3. COX SARS-CoV
  4. Proglumetacin

Proglumetacin 是一种口服有效的环加氧酶 (cyclo-oxygenase) 抑制剂。Proglumetacin 可以抑制 SARS-CoV Mpro (新冠病毒的主要蛋白酶)，其 AC50 为 8.9 μM。Proglumetacin 具有抗炎活性，可用于炎症(如类风湿关节炎、过敏性气囊炎)的研究。

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Proglumetacin Chemical Structure

Proglumetacin Chemical Structure

CAS No. : 57132-53-3

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Proglumetacin 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Proglumetacin is an orally active and potent cyclo-oxygenase inhibitor. Proglumetacin can inhibits SARS-CoV Mpro (main protease of the SARS-CoV-2), with an AC50 of 8.9 μM (activity concentration at half maximal activity). Proglumetacin has anti-inflammatory activity, can be used for inflammation (such as Rheumatoid arthritis, and Allergic air pouch inflammation) research[1][2][3].

体外研究
(In Vitro)

Proglumetacin strongly inhibits 5-HETE formation, with an IC50 of 1.5 μM[2].
Proglumetacin inhibits leukocyte migration by inhibiting the production of the chemotactic cyclo-oxygenase product thromboxane B2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Proglumetacin 相关抗体:
体内研究
(In Vivo)

Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (6 weeks)
Dosage: 0, 0.3, 3, 9, 30 mg/kg
Administration: Orally, once
Result: Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content.
分子量

844.43

Formula

C46H58ClN5O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Proglumetacin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proglumetacin57132-53-3COXSARS-CoVCyclooxygenaseSARS coronavirusAnti-inflammatory activityOrally activeRheumatoid arthritisSARS-CoV-2Allergic air pouch inflammationInhibitorinhibitorinhibit

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