2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. PROTAC AR Degrader-5

PROTAC AR Degrader-5 (compound A46) 是一种有效的 AR PROTAC 降解剂，IC50 值为 49 nM。PROTAC AR Degrader-5 抑制皮脂斑并诱导毛发再生。

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PROTAC AR Degrader-5 Chemical Structure

PROTAC AR Degrader-5 Chemical Structure

CAS No. : 2703021-51-4

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PROTAC AR Degrader-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC AR Degrader-5 (compound A46) is a potent AR PROTAC Degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration[1].

体内研究
(In Vivo)

PROTAC AR Degrader-5 (compound A46) (100, 200, 400, 800 µg + 12 µg TP; Skin application; daily for 21 days) 抑制金仓鼠的皮脂斑[1]。
PROTAC AR Degrader-5 (5, 10, 30 mg/ml +DHT 30 mpk; 150 µL; Skin application; 2 times a day for 17 days) 诱导 C57BL/6N 小鼠毛发再生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-8 weeks, 90-110g, Female Golden hamster[1]
Dosage: 100, 200, 400, 800 µg + 12 µg TP
Administration: Skin application; daily for 21 days
Result: Inhibited sebaceous plaque with the inhibition rate of 19.24%, 35.20%, 49.54%, 51.61% at 100, 200, 400, 800 µg, respectively.
分子量

1043.16

Formula

C52H54F4N8O7S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC AR Degrader-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC AR Degrader-52703021-51-4PROTAC AR Degrader5PROTAC AR Degrader 5Androgen ReceptorInhibitorinhibitorinhibit

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目录号：
HY-160547
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