1. PROTAC Protein Tyrosine Kinase/RTK
  2. PROTACs c-Met/HGFR
  3. PROTAC c-Met degrader-1

PROTAC c-Met degrader-1 (Compound Met-DD4) 是口服有效的 PROTAC 降解剂,对 c-MetDC50 为 6.21 nM。PROTAC c-Met degrader-1 抑制 c-Met 成瘾细胞 MKN-45 的增殖,IC50 为 4.37 nM,并在 G0/G1 期阻滞细胞周期。PROTAC c-Met degrader-1 在 MKN-45 异种移植小鼠模型中表现出抗肿瘤活性。(粉色:靶蛋白配体 (HY-13404);蓝色:E3 连接酶配体 (HY-W087383);黑色:连接子 (HY-W074901))

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PROTAC c-Met degrader-1 Chemical Structure

PROTAC c-Met degrader-1 Chemical Structure

CAS No. : 3056647-52-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC c-Met degrader-1 (Compound Met-DD4) is an orally active PROTAC degrader for c-Met with a DC50 of 6.21 nM. PROTAC c-Met degrader-1 inhibits the proliferation of c-Met-addicted cell MKN-45 with an IC50 of 4.37 nM, and arrests the cell cycle at G0/G1 phase. PROTAC c-Met degrader-1 exhibits antitumor efficacy in MKN-45 xenograft mouse models[1]. (Pink: Ligand for target protein (HY-13404); Blue: Ligand for E3 ligase (HY-W087383); Black: Linker (HY-W074901))

IC50 & Target

c-Met

6.21 nM (DC50)

分子量

820.87

Formula

C45H41FN10O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PROTAC c-Met degrader-1
目录号:
HY-168135
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