1. PROTAC Epigenetics Cell Cycle/DNA Damage
  2. PROTACs HDAC
  3. PROTAC HDAC6 degrader 4

PROTAC HDAC6 degrader 4 (Compound 17c) 是 HDAC6PROTAC 降解剂,DC50 为 14 nM。PROTAC HDAC6 degrader 4 对 HDAC1HDAC2HDAC3HDAC6 表现出抑制活性,IC50 分别为 2.2、2.37、0.61 和 0.295 μM。(Pink: ligand for target protein HDAC6 ligand-3 (HY-172360); Black: linker (HY-138387); Blue: ligand for cereblon E3 ligase (HY-W093272))

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PROTAC HDAC6 degrader 4 Chemical Structure

PROTAC HDAC6 degrader 4 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC HDAC6 degrader 4 (Compound 17c) is the PROTAC degrader for HDAC6 with a DC50 of 14 nM. PROTAC HDAC6 degrader 4 exhibits inhibitory activit against HDAC1, HDAC2, HDAC3 and HDAC6 with IC50s of 2.2, 2.37, 0.61 and 0.295 μM, respectively[1]. (Pink: ligand for target protein HDAC6 ligand-3 (HY-172360); Black: linker (HY-138387); Blue: ligand for cereblon E3 ligase (HY-W093272))

IC50 & Target

HDAC6

14 nM (DC50)

HDAC6

0.295 μM (IC50)

HDAC3

0.611 μM (IC50)

HDAC1

2.2 μM (IC50)

HDAC2

2.37 μM (IC50)

分子量

767.81

Formula

C39H42FN9O7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

PROTAC HDAC6 degrader 4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
PROTAC HDAC6 degrader 4
目录号:
HY-172359
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