2. Epigenetics PROTAC
  3. Epigenetic Reader Domain PROTACs
  4. PROTAC SMARCA2/4-degrader-34

PROTAC SMARCA2/4-degrader-34 (compound 38) 是一种有效的 SMARCA2 和 SMARCA4 PROTAC 降解剂。PROTAC SMARCA2/4-degrader-34 显示出 PXR 结合亲和力，DC50 值为 85.1 nM。PROTAC SMARCA2/4-degrader-34 降低 3xFLAG-PXR 的蛋白质表达。(粉色: 靶蛋白的配体 (HY-169280); 黑色: 连接子 (HY-43048); 蓝色: E3 连接酶的配体 (HY-125845))。

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PROTAC SMARCA2/4-degrader-34 Chemical Structure

PROTAC SMARCA2/4-degrader-34 Chemical Structure

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PROTAC SMARCA2/4-degrader-34 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC50 value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845)[1].

分子量

1127.35

Formula

C58H78N8O13S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC SMARCA2/4-degrader-34 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2/4-degrader-34Epigenetic Reader DomainPROTACsSNU-C4 3xFLAG-PXR KI cellsSNU-C4 cells3xFLAG-PXRcytotoxicInhibitorinhibitorinhibit

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产品名称：
PROTAC SMARCA2/4-degrader-34
目录号：
HY-169279
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