2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC SMARCA2/4 degrader-36

PROTAC SMARCA2/4 degrader-36 (Compound 29) 是一种有效的 SMARCA2/4 双重降解剂，其对 SMARCA2 和 SMARCA4 的 DC50 值分别为 0.22 nM 和 0.85 nM。PROTAC SMARCA2/4 degrader-36 具有抗细胞增殖活性 (粉色: 靶蛋白配体 (HY-170354); 黑色: Linker (HY-W895794); 蓝色: E3 连接酶配体 (HY-170353); E3 连接酶配体-Linker 偶联物 (HY-170356))。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

PROTAC SMARCA2/4 degrader-36 Chemical Structure

PROTAC SMARCA2/4 degrader-36 Chemical Structure

CAS No. : 3033588-00-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PROTAC SMARCA2/4 degrader-36 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC SMARCA2/4 degrader-36 (Compound 29) is an effective dual degrader of SMARCA2/4, with DC50 values of 0.22 nM and 0.85 nM for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2/4 degrader-36 has anti-cell proliferation activity (Pink: Target Protein Ligand (HY-170354); Black: Linker (HY-W895794); Blue: E3 Ligase Ligand (HY-170353); E3 Ligase Ligand-Linker Conjugate (HY-170356))[1].

IC50 & Target

DC50: 0.22 nM (SMARCA2)[1].
DC50: 0.85 nM (SMARCA4)[1].
体外研究
(In Vitro)

PROTAC SMARCA2/4 degrader-36 (Compound 29) (6 天) 能抑制显著 NCIH838 和 Calu-6 细胞的增殖，其 gIC50 值分别为 3.0 nM 和 280 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC SMARCA2/4 degrader-36 相关抗体:
体内研究
(In Vivo)

PROTAC SMARCA2/4 degrader-36 (Compound 29) (1-10 mg/kg; i.v.; 单剂量) 能降低小鼠肿瘤组织中的 SMARCA2 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

956.64

Formula

C53H62ClN9O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC SMARCA2/4 degrader-36 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2/4 degrader-363033588-00-7PROTACsEpigenetic Reader DomainNCIH838Calu-6antiproliferative activityInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PROTAC SMARCA2/4 degrader-36
目录号：
HY-170347
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z