2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. Protease-Activated Receptor-1, PAR-1 Agonist

Protease-Activated Receptor-1, PAR-1 Agonist 

目录号: HY-P2518 纯度: 98.34%
COA 产品使用指南

摩尔计算器

Protease-Activated Receptor-1, PAR-1 Agonist 是一种选择性蛋白酶激活受体1 (PAR-1) 激动肽。Protease-Activated Receptor-1, PAR-1 Agonist 对应于PAR1配体，可通过该受体选择性地模拟凝血酶的作用。

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Custom Peptide Synthesis

Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure

Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure

CAS No. : 141136-85-8

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥500
In-stock
5 mg ￥1250
In-stock
10 mg ￥1900
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Other Forms of Protease-Activated Receptor-1, PAR-1 Agonist:

Protease-Activated Receptor-1, PAR-1 Agonist 相关抗体

Top Publications Citing Use of Products

查看 Protease Activated Receptor (PAR) 亚型特异性产品:

查看所有亚型
PAR1 PAR2 PAR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].

IC50 & Target

PAR1

 

体外研究
(In Vitro)

Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor G? 6976[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Protease-Activated Receptor-1, PAR-1 Agonist 相关抗体:
分子量

762.90

Formula

C35H58N10O9
CAS 号
性状

固体

颜色

White to off-white

Sequence

Thr-Phe-Leu-Leu-Arg-Asn
Sequence Shortening

TFLLRN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 12.5 mg/mL (16.38 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3108 mL 6.5539 mL 13.1079 mL
5 mM 0.2622 mL 1.3108 mL 2.6216 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Protease-Activated Receptor-1, PAR-1 Agonist 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3108 mL 6.5539 mL 13.1079 mL 32.7697 mL
5 mM 0.2622 mL 1.3108 mL 2.6216 mL 6.5539 mL
10 mM 0.1311 mL 0.6554 mL 1.3108 mL 3.2770 mL
15 mM 0.0874 mL 0.4369 mL 0.8739 mL 2.1846 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protease-Activated Receptor-1, PAR-1 Agonist141136-85-8Protease Activated Receptor (PAR)Thrombin receptorsprotease-activatedreceptorPAR-1thrombinInhibitorinhibitorinhibit

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