2. 重组蛋白
  3. Chemokine & Receptors
  4. CXC Chemokines
  5. SDF-1/CXCL12
  6. CXCL12/SDF-1 alpha

CXCL12/SDF-1 alpha  (重组人基质细胞衍生因子-1α)

重组蛋白定制服务

SDF-1 α（基质细胞衍生因子 1α，SDF-1α）是缺乏 ELR 结构域的趋化因子 α 亚家族的成员。SDF-1α 作为 T 和 B 淋巴细胞和单核细胞的化学引诱物。SDF-1α 是 CXCR4 的配体。SDF-1α/CXCR4 信号介导许多生理过程，包括细胞运输、血管生成、胚胎发生、肿瘤侵袭和转移。它还控制归巢到骨髓的造血干细胞的趋化性。SDF-1是趋化因子家族的重要成员，以 SDF-1α 和 SDF-1β 两种亚型表达，其中 SDF-1α 是主要亚型。SDF-1α 广泛存在于人体多种组织器官中，如淋巴结、骨髓、肝、肺、肌肉、小肠、肾、脑等，并能持续存在于这些器官和组织中。研究表明，SDF-1α 在各种细胞的迁移、分布、发育、分化和凋亡等生理功能中发挥着重要作用。此外，SDF-1α 在炎症、肿瘤形成和转移、病原体感染、伤口修复等一些疾病的病理过程中发挥着关键作用[1][3]。
SDF-1 具有 α、β 和 γ 三种亚型，它们在剪接水平上不同，而不是在转录水平上。对人和小鼠中 SDF-1 的基因组结构的分析揭示了两种同种型 SDF-1α 和 SDF-1β，它们由单个基因编码并由可变剪接产生。SDF-1α 由 3 个外显子组成，编码 89 个氨基酸的蛋白质，而 SDF-1β 由 4 个外显子组成，编码 93 个氨基酸的蛋白质。两种亚型的序列高度相似，仅在 SDF1β 的 C 端增加了 4 个氨基酸。在成年大鼠脑中，SDF-1α 是主要的一种，存在于星形胶质细胞、小胶质细胞以及神经元中。SDF-1α 在正常胆碱能神经元中发现阳性，例如在内侧隔和无名质中，在多巴胺能神经元中，例如在黑质 (SN) 致密部和腹侧被盖区域中。SDF-1α 是 CXCR4 的配体。CXCR4 也是人类免疫缺陷病毒 (HIV) 结合的靶标[1][2]。

SDF-1 alpha (Stromal Cell-Derived Factor-1α, SDF-1α) is a member of the chemokine α subfamily that lack the ELR domain. SDF-1α works as a chemoattractant for T- and B-lymphocytes and monocytes. SDF-1α is a ligand for CXCR4. The SDF-1α/CXCR4 signaling mediates many physiological processes including cell trafficking, angiogenesis, embryogenesis, tumor invasion and metastatic. It also controls the chemotaxis of hematopoietic stem cells homing to the bone marrow. SDF-1, an important member of the chemokine family, is expressed in two subtypes, SDF-1α and SDF-1β, with SDF-1α being the main subtype. SDF-1α is widely present in many tissues and organs of the human body, such as the lymph nodes, bone marrow, liver, lung, muscle, small intestine, kidney, and brain, and can sustainably exist in these organs and tissues. Studies have shown that SDF-1α plays an important role in the physiological mfunctions of migration, distribution, development, differentiation, and apoptosis of various cells. Moreover, SDF-1α plays a key role in the pathological process of some diseases, such as inflammation, tumor formation and metastasis, pathogen infection, and wound repair[1][3].
SDF-1 has three isoforms, α, β, and γ, which are different at the splicing level, not at the transcriptional level. The analysis of the genomic structure of SDF-1 in human and mouse revealed two isoforms, SDF-1α and SDF-1β, which are encoded by a single gene and result from alternative splicing. SDF-1α comprises 3 exons and encodes a protein of 89 amino acids whereas SDF-1β consists of 4 exons and encodes a protein of 93 amino acids. Both isoforms are highly similar regarding their sequences with the only difference of 4 additional amino acids at the C-terminus of SDF1β. In adult rat brain, SDF-1α is the predominant one, present in astrocytes, microglia, as well as in neurons. SDF-1α is found positive in normal cholinergic neurons, such as in the medial septum and substantia innominata, and in dopaminergic neurons, such as in the substantia nigra (SN) pars compacta and the ventral tegmental area. SDF-1α is the only known ligand for CXCR4. CXCR4 is also a target for human immunodeficiency virus (HIV) binding[1][2].

目录号 产品名 / 同用名 种属 表达系统
  • HY-P700043AF
    Animal-Free SDF-1 alpha/CXCL12 Protein, Human (His)

    Stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1

    		Human E. coli
    SDF-1 α/CXCL12 蛋白是免疫细胞的趋化剂。Animal-Free SDF-1 Beta/CXCL12 Protein, Human (His) 是重组的 无动物源 SDF-1 Beta/CXCL12 蛋白，由 E. coli 表达，带有 C-His 标签。Animal-Free SDF-1 Beta/CXCL12 Protein, Human (His) 全长 65 个氨基酸，分子量约为 ~8.55 kDa。
  • HY-P7403
    SDF-1 alpha/CXCL12 Protein, Mouse (68a.a, CHO)

    重组小鼠基质细胞衍生因子-1α/CXCL12 (CHO 表达)

    rMuSDF-1α/CXCL12; SDF-1; PBSF; C-X-C motif chemokine 12; TLSF

    		Mouse CHO
    SDF-1 alpha (基质细胞衍生因子 1α，SDF-1α) 是缺乏 ELR 结构域的趋化因子 α 亚家族的成员。SDF-1α 作为 T 和 B 淋巴细胞和单核细胞的趋化剂。SDF-1α 是CXCR4 的配体。SDF-1α/CXCR4 信号介导许多生理过程，包括细胞运输、血管生成、胚胎发生、肿瘤侵袭和转移。它还控制归巢到骨髓的造血干细胞的趋化性。SDF-1 alpha/CXCL12 Protein, Mouse (CHO) 在 CHO 细胞中表达产生。
  • HY-P70469
    SDF-1 alpha/CXCL12 Protein, Human

    Stromal Cell-Derived Factor 1; SDF-1; hSDF-1; C-X-C Motif Chemokine 12; Intercrine Reduced in Hepatomas; IRH; hIRH; Pre-B Cell Growth-Stimulating Factor; PBSF; CXCL12; SDF1; SDF1A; SDF1B

    		Human E. coli
    SDF-1 α/CXCL12 蛋白是免疫细胞的趋化剂。SDF-1 alpha/CXCL12 Protein, Human 是重组的 SDF-1 α/CXCL12 蛋白，由 E. coli 表达，不带标签。
  • HY-P73661
    SDF-1 alpha/CXCL12 Protein, Human (His)

    重组人CXCL12蛋白

    Stromal Cell-Derived Factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1

    		Human E. coli
    SDF-1 alpha (基质细胞衍生因子 1α，SDF-1α) 是缺乏 ELR 结构域的趋化因子 α 亚家族的成员。SDF-1α 作为 T 和 B 淋巴细胞和单核细胞的趋化剂。SDF-1α 是CXCR4 的配体。SDF-1α/CXCR4 信号介导许多生理过程，包括细胞运输、血管生成、胚胎发生、肿瘤侵袭和转移。它还控制归巢到骨髓的造血干细胞的趋化性。SDF-1 alpha/CXCL12 Protein, Human (His) 在大肠杆菌中表达产生，由 68 个氨基酸 (K22-K89) 组成，并在 N 端带有 His 标签。
  • HY-P7285
    SDF-1 alpha/CXCL12 Protein, Mouse

    重组小鼠基质细胞衍生因子-1α/CXCL12

    rMuSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF

    		Mouse E. coli
    SDF-1 alpha (基质细胞衍生因子 1α，SDF-1α) 是缺乏 ELR 结构域的趋化因子 α 亚家族的成员。SDF-1α 作为 T 和 B 淋巴细胞和单核细胞的趋化剂。SDF-1α 是CXCR4 的配体。SDF-1α/CXCR4 信号介导许多生理过程，包括细胞运输、血管生成、胚胎发生、肿瘤侵袭和转移。它还控制归巢到骨髓的造血干细胞的趋化性。SDF-1 alpha/CXCL12 Protein, Mouse 在大肠杆菌中表达产生。
  • HY-P7286
    SDF-1 alpha/CXCL12 Protein, Rat

    重组大鼠基质细胞衍生因子-1α/CXCL12

    rRtSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF

    		Rat E. coli
    SDF-1 alpha (基质细胞衍生因子 1α，SDF-1α) 是缺乏 ELR 结构域的趋化因子 α 亚家族的成员。SDF-1α 作为 T 和 B 淋巴细胞和单核细胞的趋化剂。SDF-1α 是CXCR4 的配体。SDF-1α/CXCR4 信号介导许多生理过程，包括细胞运输、血管生成、胚胎发生、肿瘤侵袭和转移。它还控制归巢到骨髓的造血干细胞的趋化性。SDF-1 alpha/CXCL12 Protein, Rat 在大肠杆菌中表达产生。
目录号 产品名 作用方式 纯度
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