2. 天然产物
  3. 植物 黄酮类
  4. 金星蕨科 黄酮
  5. 普通针毛蕨
  6. Protoapigenone

Protoapigenone 是一种抗肿瘤剂，可从蕨类植物中分离得到。Protoapigenone 对 Hep G2、Hep 3B、MCF-7、A549 和 MDAMB-231 具有显著抑制活性，IC50s 值分别为 1.60、0.23、0.78、3.88 和 0.27 μg/mL。

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Protoapigenone Chemical Structure

Protoapigenone Chemical Structure

CAS No. : 862884-32-0

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规格 价格 是否有货 数量
1 mg ￥3500
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Protoapigenone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC50s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
13.85 μM
Compound: 1
Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method
Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method
[PMID: 17622129]
HEK293 IC50
6.79 μM
Compound: 1
Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
Hep 3B2 IC50
2.27 μM
Compound: 1
Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method
Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method
[PMID: 17622129]
HepG2 IC50
7.77 μM
Compound: 1
Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
HepG2 IC50
8.11 μM
Compound: 1
Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method
Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method
[PMID: 17622129]
MCF7 IC50
3.74 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method
Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method
[PMID: 17622129]
MCF7 IC50
5.5 μM
Compound: 1
Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
MDA-MB-231 IC50
1.43 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method
[PMID: 17622129]
MDA-MB-231 IC50
1.7 μM
Compound: 1
Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
PANC-1 IC50
22.09 μM
Compound: 1
Antitumor activity against human PANC1 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human PANC1 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
PBMC IC50
8.11 μM
Compound: 1
Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay
Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
PC-3 IC50
6.13 μM
Compound: 1
Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
RPMI-8226 IC50
3.93 μM
Compound: 1
Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
SK-OV-3 IC50
0.71 μM
Compound: 1
Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
U-266 IC50
7.66 μM
Compound: 1
Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay
Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay
[PMID: 21515048]
分子量

286.24

Formula

C15H10O6
CAS 号
性状

固体

颜色

White to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Protoapigenone 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protoapigenone862884-32-0Othersantineoplastic agentInhibitorinhibitorinhibit

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