2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Protoporphyrin IX disodium

Protoporphyrin IX disodium  (Synonyms: 原卟啉 IX (二钠))

目录号: HY-B1247A
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摩尔计算器

Protoporphyrin IX disodium 是血红素生物合成途径中的最终中间体。Protoporphyrin IX disodium 作为辐射敏化剂，即使在缺氧状态下也能增强 ROS 的生成并诱导 DNA 损伤。Protoporphyrin IX disodium 也作为光敏剂，通过光照射直接降解发生光漂白。Protoporphyrin IX disodium 在给药 5-aminolevulinic acid (5-ALA) (HY-W000450) 后在大鼠肿瘤细胞中形成和积累。当激活峰值波长为 405 nm 的红色荧光时，Protoporphyrin IX disodium 引起基底细胞癌的选择性改善。Protoporphyrin IX disodium 有望用于声动力和光动力对癌症的药物研究，如膀胱癌和结节性基底细胞癌。

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Protoporphyrin IX disodium Chemical Structure

Protoporphyrin IX disodium Chemical Structure

CAS No. : 50865-01-5

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Protoporphyrin IX disodium 的其他形式现货产品:

Other Forms of Protoporphyrin IX disodium:

Protoporphyrin IX disodium 相关抗体

Top Publications Citing Use of Products

    Protoporphyrin IX disodium purchased from MCE. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259.  [Abstract]

    Protoporphyrin IX (PpIX; 0, 5, 15, 25 µM; 2 h) rapidly results in increased nuclear G4 levels in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

    Protoporphyrin IX disodium purchased from MCE. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73.  [Abstract]

    To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma[1][2][3][4][5].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外研究
    (In Vitro)

    Protoporphyrin IX disodium (3.6 nmol/g 组织) 组织在光照下能引起正常大鼠结肠黏膜坏死[4]。
    Protoporphyrin IX disodium (6.6 nmol/g 肿瘤) 在大鼠肿瘤辐照后延缓肿瘤生长[4]。
    Protoporphyrin IX disodium (0-25 μM, 2 小时) 迅速导致 Hela 细胞中核 G4 水平升高[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Protoporphyrin IX disodium 相关抗体:
    体内研究
    (In Vivo)

    Aminolevulinic acid (300 mg/kg, 单次静脉注射) 给药 3 小时后，大鼠肝脏和肠道中 Protoporphyrin IX disodium 含量最高 (约 6.3 nmol/g 组织)，其次是主动脉 (4.3 nmol/g 组织) 和食道 (2.1 nmol/g 组织)[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    606.62

    Formula

    C34H32N4Na2O4
    CAS 号
    中文名称

    原卟啉 IX (二钠)
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Protoporphyrin IX disodium 相关分类

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    Keywords:

    Protoporphyrin IX disodium50865-01-5原卟啉 IX (二钠)Endogenous Metaboliteintermediateheme biosynthetictumor cellsratsenterohepatic circulationbasal cell carcinomasonodynamicphotodynamicbladder cancerInhibitorinhibitorinhibit

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