2. GPCR/G Protein
  3. Adenosine Receptor
  4. PSB-603

PSB-603 是一种有效的高选择性 A2B 腺苷受体拮抗剂，Ki 为 0.553 nM，对人和大鼠 A1 和 A2A 以及人 A3 受体几乎没有亲和力。

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PSB-603 Chemical Structure

PSB-603 Chemical Structure

CAS No. : 1092351-10-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1629
In-stock
1 mg ￥700
In-stock
5 mg ￥1400
In-stock
10 mg ￥2400
In-stock
25 mg ￥5200
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

PSB-603 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Jurkat IC50
1.13 nM
Compound: 35
Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2
Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2
[PMID: 19569717]
体外研究
(In Vitro)

PSB-603 is a potent and selective adenosine A2B receptor antagonist exhibiting a Ki value of 0.553 nM at the human A2B receptor and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSB-603 相关抗体:

Cell Viability Assay[3]

Cell Line: Peripheral T cells
Concentration: 100 nM
Incubation Time: 24 hours
Result: Significantly inhibited NECA stimulated IL-6 release ≈3-fold.
体内研究
(In Vivo)

PSB-603 shows anti-inflammatory effect in local and systemic inflammation models. PSB-603 (5 mg/kg b.w. ip) significantly reduces inflammation in two mice models of inflammation (local and systemic). PSB-603 significantly decreases levels of the inflammatory cytokines IL-6, TNF-α and of ROS in the inflamed paw and reduces inflammation of the peritoneum by significantly decreasing the infiltration of leukocytes[4]. PSB-603 is administered as suspensions in 1 % Tween 80[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Albino Swiss mice, CD-1, weighing 25-30 g[4]
Dosage: 1, 5 or 10 mg/kg
Administration: Administered intraperitoneally (ip), prior to carrageenan injection
Result: Carrageenan-induced edema model. The increase in paw oedema was significantly inhibited in all groups receiving PSB-603. The dose of 5 mg/kg turned out to be the most active.
分子量

529.01

Formula

C24H25ClN6O4S
CAS 号
性状

固体

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 32.5 mg/mL (61.44 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8903 mL 9.4516 mL 18.9032 mL
5 mM 0.3781 mL 1.8903 mL 3.7806 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： 50% PEG300    50% Saline

    Solubility: 1.67 mg/mL (3.16 mM); 悬浊液; Need ultrasonic and warming and heat to 42°C

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (258 KB)

产品使用指南 (1538 KB)
参考文献

PSB-603 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8903 mL 9.4516 mL 18.9032 mL 47.2581 mL
5 mM 0.3781 mL 1.8903 mL 3.7806 mL 9.4516 mL
10 mM 0.1890 mL 0.9452 mL 1.8903 mL 4.7258 mL
15 mM 0.1260 mL 0.6301 mL 1.2602 mL 3.1505 mL
20 mM 0.0945 mL 0.4726 mL 0.9452 mL 2.3629 mL
25 mM 0.0756 mL 0.3781 mL 0.7561 mL 1.8903 mL
30 mM 0.0630 mL 0.3151 mL 0.6301 mL 1.5753 mL
40 mM 0.0473 mL 0.2363 mL 0.4726 mL 1.1815 mL
50 mM 0.0378 mL 0.1890 mL 0.3781 mL 0.9452 mL
60 mM 0.0315 mL 0.1575 mL 0.3151 mL 0.7876 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-6031092351-10-4PSB603PSB 603Adenosine ReceptorP1 receptoradenosineA2Banti-inflammatoryinflammatorycytokinesIL-6TNF-αROSInhibitorinhibitorinhibit

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产品名称：
PSB-603
目录号：
HY-103166
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