2. Anti-infection Apoptosis
  3. Antibiotic Fungal Apoptosis
  4. Pyoluteorin

Pyoluteorin  (Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

目录号: HY-114979 纯度: 99.90%
COA 产品使用指南

摩尔计算器

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

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Pyoluteorin Chemical Structure

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

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1 mg ￥2400
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Pyoluteorin 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

体外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pyoluteorin 相关抗体:

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.
分子量

272.08

Formula

C11H7Cl2NO3
CAS 号
性状

固体

颜色

Off-white to yellow

中文名称

藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (459.42 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6754 mL 18.3769 mL 36.7539 mL
5 mM 0.7351 mL 3.6754 mL 7.3508 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.90%

COA (291 KB) HNMR (134 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

Pyoluteorin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6754 mL 18.3769 mL 36.7539 mL 91.8847 mL
5 mM 0.7351 mL 3.6754 mL 7.3508 mL 18.3769 mL
10 mM 0.3675 mL 1.8377 mL 3.6754 mL 9.1885 mL
15 mM 0.2450 mL 1.2251 mL 2.4503 mL 6.1256 mL
20 mM 0.1838 mL 0.9188 mL 1.8377 mL 4.5942 mL
25 mM 0.1470 mL 0.7351 mL 1.4702 mL 3.6754 mL
30 mM 0.1225 mL 0.6126 mL 1.2251 mL 3.0628 mL
40 mM 0.0919 mL 0.4594 mL 0.9188 mL 2.2971 mL
50 mM 0.0735 mL 0.3675 mL 0.7351 mL 1.8377 mL
60 mM 0.0613 mL 0.3063 mL 0.6126 mL 1.5314 mL
80 mM 0.0459 mL 0.2297 mL 0.4594 mL 1.1486 mL
100 mM 0.0368 mL 0.1838 mL 0.3675 mL 0.9188 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyoluteorin25683-07-2藤黄绿菌素藤黄绿脓菌素黄绿脓菌素AntibioticFungalApoptosisOomycetefungiPythiumultimumfungusMDA-MB-231triple-negativebreastcancerapoptosiscellcyclearrestInhibitorinhibitorinhibit

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