2. Anti-infection
  3. Parasite
  4. Pyronaridine

Pyronaridine 是一种具有口服活性的、含甘露醇的抗疟疾试剂。Pyronaridine 对 P. falciparum 和 Echinococcus granulosus 均具有抗感染活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Pyronaridine tetraphosphate 通常具有更好的水溶性和稳定性。

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Pyronaridine Chemical Structure

Pyronaridine Chemical Structure

CAS No. : 74847-35-1

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Pyronaridine 的其他形式现货产品:

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Other Forms of Pyronaridine:

Pyronaridine 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.00179 μM
Compound: Pyronaridine
Cytotoxicity against HEK293 cells assessed as cell viability after 72 hrs by resazurin-based plate reader analysis
Cytotoxicity against HEK293 cells assessed as cell viability after 72 hrs by resazurin-based plate reader analysis
[PMID: 26651537]
HEK293 IC50
1.8 μM
Compound: Pyronaridine
Growth inhibition of HEK293 cells after 72 hrs by PrestoBlue staining based fluorescence assay
Growth inhibition of HEK293 cells after 72 hrs by PrestoBlue staining based fluorescence assay
[PMID: 28001067]
HEK293 IC50
1.99 μM
Compound: Pyronaridine
Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye-based fluorescence assay
Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye-based fluorescence assay
[PMID: 30865443]
HEK293 IC50
2.9 μM
Compound: Pyronaridine
Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
[PMID: 29236492]
HEK293 CC50
3549.5 nM
Compound: Pyronaridine
Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
[PMID: 30537832]
HEK293 IC50
5.2 μM
Compound: Pyronaridine
Cytotoxicity against human HEK293 cells after 72 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HEK293 cells after 72 hrs by resazurin dye based fluorescence assay
[PMID: 29969262]
HeLa IC50
0.82 μM
Compound: Pyronaridine
Antiviral activity against Ebolavirus infected in human HeLa cells assessed as reduction in viral replication incubated for 48 hrs by luminescence based assay
Antiviral activity against Ebolavirus infected in human HeLa cells assessed as reduction in viral replication incubated for 48 hrs by luminescence based assay
[PMID: 32832035]
HeLa IC50
3.1 μM
Compound: Pyronaridine
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo assay
[PMID: 36208544]
HepG2 IC50
< 1 μM
Compound: Pyronaridine
Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin
Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin
[PMID: 23927658]
HT-1080 IC50
4.23 μM
Compound: Pyronaridine
Anticancer activity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
Anticancer activity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
[PMID: 36208544]
Jurkat IC50
4 μM
Compound: (4) Pyronaridine
Concentration required to reduce growth of human jurkat leukemia cells to 50% of control cultures, determined using a 72 hr continuous exposure
Concentration required to reduce growth of human jurkat leukemia cells to 50% of control cultures, determined using a 72 hr continuous exposure
[PMID: 8182707]
SH-SY5Y IC50
1.7 μM
Compound: Pyronaridine
Anticancer activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
Anticancer activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
[PMID: 36208544]
SK-N-AS IC50
3.45 μM
Compound: Pyronaridine
Anticancer activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
Anticancer activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based fluorescence assay
[PMID: 36208544]
体外研究
(In Vitro)

Pyronaridine (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pyronaridine 相关抗体:
体内研究
(In Vivo)

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) reduces the parasitic burden in the Echinococcus granulosus-infected mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) reduces the parasitic burden in secondarily infected (cysts) mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) exhibits a higher exposure in the liver than in the plasma in male ICR mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Echinococcus granulosus-infected mice model[2]
Dosage: 57 mg/kg
Administration: Oral administration, q.d. for 30 days
Result: Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.
Clinical Trial
分子量

518.05

Formula

C29H32ClN5O2
CAS 号
中文名称

咯萘啶
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pyronaridine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyronaridine74847-35-1咯萘啶ParasiteArtesunatemalariadrug resistantcystCEechinococcosisinfectionInhibitorinhibitorinhibit

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