2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Fungal
  4. Quinizarin

Quinizarin  (Synonyms: 1,4-二羟基蒽醌; 1,4-Dihydroxyanthraquinone)

目录号: HY-D0226 纯度: ≥98.0%
COA 产品使用指南 技术支持

Quinizarin (1,4-Dihydroxyanthraquinone) 是 Doxorubicin、Daunorubicin、Adriamycin 等抗癌活性分子的一部分，通过插入方式与 DNA 相互作用 (Kd=86.1 μM)。Quinizarin 是一种杀菌剂和杀虫剂，并已显示出抑制肿瘤细胞生长的能力。

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Quinizarin Chemical Structure

Quinizarin Chemical Structure

CAS No. : 81-64-1

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550
In-stock
1 g ￥500
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Customer Review

Other Forms of Quinizarin:

Quinizarin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 200 μM
Compound: Quinizarin
Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 30846253]
Ca-Ski IC50
> 10 μM
Compound: 1
Cytotoxicity against human CaSki cells after 72 hrs by MTT assay
Cytotoxicity against human CaSki cells after 72 hrs by MTT assay
[PMID: 24657570]
HeLa IC50
> 200 μM
Compound: Quinizarin
Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 30846253]
HepG2 IC50
> 200 μM
Compound: Quinizarin
Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 30846253]
L02 IC50
> 200 μM
Compound: Quinizarin
Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 30846253]
MCF7 IC50
> 200 μM
Compound: Quinizarin
Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 30846253]
MDA-MB-231 IC50
> 200 μM
Compound: Quinizarin
Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
[PMID: 30846253]
体外研究
(In Vitro)

1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped cellulose (CL) (denoted as 1,4-DHAQ@CL) microporous nanofiber film has been achieved via simple electrospinning and subsequent deacetylating, and used for highly sensitive and selective fluorescence detection of Cu(2+) in aqueous solution[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinizarin 相关抗体:
分子量

240.21

Formula

C14H8O4
CAS 号
性状

固体

颜色

Orange to red

Emission (Em)

456
Excitation (Ex)

424
中文名称

1,4-二羟基蒽醌；醌茜
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3.33 mg/mL (13.86 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1630 mL 20.8151 mL 41.6302 mL
5 mM 0.8326 mL 4.1630 mL 8.3260 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (294 KB) HNMR (122 KB)

产品使用指南 (1538 KB)
参考文献

Quinizarin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1630 mL 20.8151 mL 41.6302 mL 104.0756 mL
5 mM 0.8326 mL 4.1630 mL 8.3260 mL 20.8151 mL
10 mM 0.4163 mL 2.0815 mL 4.1630 mL 10.4076 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinizarin81-64-11,4-Dihydroxyanthraquinone1,4-二羟基蒽醌醌茜DNA/RNA SynthesisFungaltumorcellgrowthDNAfungicidepesticideInhibitorinhibitorinhibit

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