2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Cytochrome P450
  4. (Rac)-Ketoconazole

(Rac)-Ketoconazole  (Synonyms: (Rac)-Ketoconazol; (Rac)-R 41400)

目录号: HY-W422288
产品使用指南

摩尔计算器

(Rac)-Ketoconazole ((Rac)-R 41400) 是一种具有口服活性的抗真菌咪唑类化合物。(Rac)-Ketoconazole 通过抑制真菌细胞膜上的一种关键酶——细胞色素 P450 依赖的 14α-甾醇去甲基化酶 (CYP51)，从而干扰真菌的麦角固醇合成，导致细胞膜的功能障碍，最终抑制真菌的生长和繁殖。(Rac)-Ketoconazole 可用于真菌感染的研究。

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(Rac)-Ketoconazole Chemical Structure

(Rac)-Ketoconazole Chemical Structure

CAS No. : 79156-75-5

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Other Forms of (Rac)-Ketoconazole:

(Rac)-Ketoconazole 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections[1].

分子量

531.43

Formula

C26H28Cl2N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-Ketoconazole 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

(Rac)-Ketoconazole79156-75-5(Rac)-Ketoconazol (Rac)-R 41400FungalCytochrome P450CYPsAntifungal activitycytochrome P450methylation enzymemembrane functionInhibitorinhibitorinhibit

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