2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Raloxifene 6-Monomethyl Ether

Raloxifene 6-Monomethyl Ether 

目录号: HY-135584
产品使用指南

摩尔计算器

Raloxifene 6-Monomethyl Ether 是一种 Raloxifene 衍生物，其抑制雌激素受体 α (estrogen receptor α)。Raloxifene 4-Monomethyl Ether 抑制 MCF-7 细胞，IC50 为 250 nM，pIC50 为 6.6。

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Raloxifene 6-Monomethyl Ether Chemical Structure

Raloxifene 6-Monomethyl Ether Chemical Structure

CAS No. : 178451-13-3

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Raloxifene 6-Monomethyl Ether 相关抗体

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC50 of 250 nM and a pIC50 of 6.6[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
250 nM
Compound: 5b'
Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro)
Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro)
[PMID: 9003514]
体外研究
(In Vitro)

Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative with a methoxy group on C6. Raloxifene 6-Monomethyl Ether holds poor ICsub>50 value because of disruption to the hydrogen bond network and steric disfavor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Raloxifene 6-Monomethyl Ether 相关抗体:
分子量

487.61

Formula

C29H29NO4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Raloxifene 6-Monomethyl Ether 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raloxifene 6-Monomethyl Ether178451-13-3Estrogen Receptor/ERRERαRaloxifenederivativemethoxyInhibitorinhibitorinhibit

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