4-1BBL/TNFSF9 蛋白, Human (His)

4-1BBL/TNFSF9 protein is a cytokine that selectively binds to TNFRSF9 and exerts its effects by inducing the proliferation of activated peripheral blood T cells. As a homotrimer, this ligand demonstrates its potential role in activation-induced cell death (AICD) and may be involved in coordinating homologous interactions between T cells and B cells/macrophages. 4-1BBL/TNFSF9 Protein, Human (His) is the recombinant human-derived 4-1BBL/TNFSF9 protein, expressed by E. coli , with N-6*His labeled tag. The total length of 4-1BBL/TNFSF9 Protein, Human (His) is 203 a.a., with molecular weight of 25.3 kDa.

4-1BBL (TNFSF9) 蛋白是一种具有显着免疫调节功能的细胞因子，与 TNFRSF9 受体结合。其相互作用可诱导活化的外周血 T 细胞增殖，表明其在 T 细胞活化和免疫反应放大中发挥作用。此外，4-1BBL 可能参与激活诱导的细胞死亡 (AICD)，这是一个调节激活免疫细胞的存活和稳态的过程。此外，该蛋白质可能在介导 T 细胞和 B 细胞/巨噬细胞之间的同源相互作用中发挥作用，有助于免疫细胞的通讯和协调。在结构上，4-1BBL 形成同源三聚体，表明其组织成三聚体复合物。这些不同的功能强调了 4-1BBL 在免疫调节和免疫系统内细胞间通讯中的关键作用。

4-1BB (human; 1 μg/mL; 16 h) leads to induction of monocyte activation and induces Myc protein production^[4].
4-1BB (human; 1 μg/mL; 1 d) prolongs survival of peripheral monocytes and (1 μg/mL; 1 h) induces expression of M-CSF^[5].
4-1BB (human; 1.2-4 μg/mL; 7 d) exhibits nhancement of cell numbers dose-dependently^[6].

Human

E. coli

N-6*His

P41273 (P52-E254)

8744  [NCBI]

PWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE

25.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.