TNFSF9 - TNF superfamily member 9 Gene

中文名称：TNF 超家族成员 9

种属: Homo sapiens

同用名: CD137L; TNLG5A; 4-1BB-L

关于 TNFSF9

功能概要

该基因编码的蛋白质是一种属于肿瘤坏死因子 (TNF) 配体家族的细胞因子。这种跨膜细胞因子是一种双向信号转导，可作为 TNFRSF9/4-1BB 的配体，TNFRSF9/4-1BB 是 T 淋巴细胞中的一种共刺激受体分子。这种细胞因子及其受体参与抗原呈递过程和细胞毒性 T 细胞的产生。受体 TNFRSF9/4-1BB 在静息 T 淋巴细胞中不存在，但在抗原刺激后迅速表达。该基因编码的配体 TNFSF9/4-1BBL 已被证明除了促进 T 淋巴细胞增殖外，还能重新激活无反应性 T 淋巴细胞。这种细胞因子也被证明是 CD8 T 细胞中最佳 CD8 反应所必需的。这种细胞因子在癌细胞系中表达，并被认为与 T 细胞-肿瘤细胞相互作用有关。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]