Animal-Free IL-17B 蛋白, Mouse (His)

IL-17B Proteinas, a key immune response regulator, stimulates THP-1 monocytic cells to release pro-inflammatory cytokines, TNF-α, and IL-1β. Its crucial role in orchestrating immune reactions and inflammatory pathways positions it as a potential modulator of immune homeostasis, making it a therapeutic intervention target for regulating inflammatory processes. Animal-Free IL-17B Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-17B protein, expressed by E. coli , with C-His, C-His labeled tag. The total length of Animal-Free IL-17B Protein, Mouse (His) is 160 a.a., with molecular weight of ~18.99 kDa.

IL-17B 蛋白是免疫反应的关键调节因子，通过特异性刺激促炎细胞因子（即肿瘤坏死因子 α (TNF-α) 和白细胞介素 1 β (IL-1β)）的释放，证明其在细胞信号传导中的功能作用，来自单核细胞系 THP-1。这一活性强调了该蛋白质在协调免疫反应和炎症途径中的重要性，将其定位为免疫稳态的潜在调节剂和旨在调节炎症过程的治疗干预的目标。

Measure by its ability to induce IL-8 secretion in HepG2 cells. The ED₅₀ for this effect is <1.5 ng/mL.

Mouse

E. coli

C-His;C-His

Q9QXT6 (H21-F180)

56069  [NCBI]

MHPRNTKGKRKGQGRPSPLAPGPHQVPLDLVSRVKPYARMEEYERNLGEMVAQLRNSSEPAKKKCEVNLQLWLSNKRSLSPWGYSINHDPSRIPADLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPQPPRPGPCRQRVVMETIAVGCTCIF

Approximately 18.99 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.