Animal-Free IL-17F 蛋白, Human (His)

IL-17F protein is a key effector cytokine in innate and adaptive immunity that maintains tissue integrity and protects against microorganisms. It acts through the IL17RA-IL17RC receptor complex, activates the NF-kappa-B and MAPkinase pathways, and induces the transcription of immune-related genes. Animal-Free IL-17F Protein, Human (His) is the recombinant human-derived animal-FreeIL-17F protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17F Protein, Human (His) is 133 a.a., with molecular weight of ~15.84 kDa.

IL-17F 蛋白是先天性和适应性免疫系统中的关键效应细胞因子，对于抗菌防御和组织完整性维护至关重要。它通过 IL17RA-IL17RC 受体复合物发挥作用，触发下游 NF-kappa-B 和 MAPkinase 通路的激活，从而导致各种免疫相关基因的转录激活。IL-17F 主要与 Th17 细胞相关，诱导中性粒细胞活化、抗菌肽产生并调节免疫耐受。它与 IL-17A 形成同二聚体和异二聚体，影响从交感神经支配到微生物群调节的多种生物过程。IL-17F 协调的复杂相互作用和信号通路强调了其在免疫反应和细胞稳态中的多方面作用。

Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED₅₀ for this effect is <20 ng/mL.

Human

E. coli

C-His

Q96PD4 (R31-Q163)

112744  [NCBI]

MRKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ

Approximately 15.84 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 20 mM sodium acetate, pH 4.0, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.