1. Gene
  2. IL17F - interleukin 17F Gene

IL17F - interleukin 17F Gene

中文名称:白细胞介素 17F

种属: Homo sapiens

同用名: ML1; ML-1; IL17A; CANDF6; IL-17F

基因 ID: 112744 | 基因类型: protein coding

关于 IL17F

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,236,681-52,245,689 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues, 5 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是一种与 IL17 具有序列相似性的细胞因子。这种细胞因子由活化的 T 细胞表达,并已显示可刺激其他几种细胞因子的产生,包括 IL6、IL8 和 CSF2/GM_CSF。还发现这种细胞因子可抑制内皮细胞的血管生成并诱导内皮细胞产生 IL2、TGFB1/TGFB 和单核细胞趋化蛋白-1。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several Other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

IL17F 基因产物(1)

mRNA Protein Name
NM_052872.4 NP_443104.1 interleukin-17F precursor

IL17F 蛋白结构

IL17

IL17: Interleukin-17 (76 - 156)

  • 0
  • 100
  • 163 a.a.
蛋白主名 其他名称

interleukin-17F

cytokine ML-1

重组 IL17F 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7209 IL-17F Protein, Human Q96PD4 (R31-Q163) ≥95%
HY-P70540 IL-17F Protein, Human (HEK293, His) Q96PD4/AAH70124.1 (R31-Q163) ≥95%
HY-P72586 IL-17F Protein, Human (HEK293) Q96PD4/AAH70124.1 (R31-Q163) ≥95%
HY-P72589 IL-17A/F Heterodimer Protein, Human (HEK293, His) Q16552 (G24-A155)&AAH70124.1 (R31-Q163) ≥95%
HY-P77713 IL-17A/F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) Q16552 (G24-A155)&Q96PD4 (R31-Q163) ≥95%
HY-P78159 IL-17F Protein, Human (Biotinylated, HEK293, His-Avi) Q96PD4 (R31-Q163) ≥95%
HY-P700107AF Animal-Free IL-17F Protein, Human (His) Q96PD4 (R31-Q163) ≥95%

关联疾病

疾病名称 别名
Candidiasis, Familial, 6

CANDF6

Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant

Candidiasis, Familial, 6, Autosomal Dominant

Autosomal Dominant Candidiasis Familial Chronic Mucocutaneous

Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome

Candf7

Candidiasis Familial, 7

Familial Chronic Mucocutaneous, Autosomal Dominant

Immunodeficiency 31c

Imd31c

Candidiasis Familial Chronic Mucocutaneous Autosomal Dominant

Chronic Mucocutaneous Candidiasis 6

Candidiasis, Familial, Type 6

Candidiasis, Familial, 7

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous

Candidiasis

Systemic Candidiasis

Invasive Candidiasis

Disseminated Candidiasis

Systemic Candida Infections

Candidiasis, Invasive

Acute Generalized Exanthematous Pustulosis

Agep

Pustular Drug Eruption

Toxic Pustuloderma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Autoimmune Polyendocrine Syndrome Type 1

Whitaker Syndrome

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

Autoimmune Polyglandular Syndrome I

Polyglandular Type I Autoimmune Syndrome

Mouth Disease

Mouth Diseases

Mouth Disorders

Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly

Cutaneous Candidiasis

Candidiasis, Cutaneous

Autoimmune Polyendocrine Syndrome

Autoimmune Polyendocrinopathy

Autoimmune Polyglandular Failure

Autoimmune Polyglandular Syndrome

Polyendocrinopathies, Autoimmune

Lloyd'S Syndrome

Aps

Polyendocrinopathies Autoimmune

Polyendocrine Autoimmunity Syndrome

Lloyd Syndrome

Polyglandular Autoimmune Deficiency

Progressive Pluriglandular Insufficiency

Pluriglandular Autoimmune Atrophy

Pluriglandular Autoimmune Syndrome

Thyroid-Adrenocortical Insufficiency Syndrome

Complement Component 6 Deficiency

C6 Deficiency

C6D

C6 Deficiency Subtotal

Complement Component 6 Deficiency Subtotal

C6 Deficiency, Subtotal

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome

Hyper-Ige Recurrent Infection Syndrome 1

Hyperimmunoglobulin E Syndrome

Job'S Syndrome

Recurring Cold Staphylococcal Abscesses

Ige Syndromes

Buckley Syndrome

Hie - [Hyperimmunoglobulin E] Syndrome

Job-Buckley Syndrome

Quie-Hill Syndrome

Psoriasis 11

PSORS11

Psoriasis Susceptibility 11

Psoriasis

Psoriasis Vulgaris

Psoriasis 11, Susceptibility To

Pv

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Autoimmune Disease Of Skin And Connective Tissue
Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Fungal Infectious Disease

Mycoses

Mycosis

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Oral Candidiasis

Thrush

Candidiasis Of Mouth

Oral Moniliasis

Thrush, Oral

Candidiasis, Oral

Oral Thrush

Candidiasis

Equine Thrush

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Dermatophytosis

Tinea

Dermatophytosis, Unspecified

Ringworm

Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

Cutaneous Mycosis

Dermal Mycosis

Superficial Mycosis, Unspecified

Fungus Infection Of Skin

Skin Mycosis

Dermatitis Fungoid

Fungal Dermatitis

Fungal Dermatosis

Mycotic Infection Of Skin

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease

Spondyloarthropathy

Spondylarthropathies

Spondarthropathy

Spondylarthrosis

Spondyloarthropathy, Susceptibility To

Spondylarthritis

Autoimmune Disease Of Eyes, Ear, Nose And Throat
Pustulosis Of Palm And Sole

Psoriasis

Acropustulosis

Palmoplantar Pustulosis

Pustular Psoriasis Of The Palms And/Or Soles

Pustulosis Of Palms And Soles

Acrodermatitis Continua Of Hallopeau

Generalized Pustular Psoriasis

Psoriasis
Autoimmune Uveitis
Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Autoimmune Disease Of Musculoskeletal System
Integumentary System Disease
Ankylosing Spondylitis 1

Ankylosing Spondylitis, Susceptibility To, 1

Autoimmune Disease Of Central Nervous System
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis

Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IL17F RGD RGD:1311398
Macaca mulatta IL17F VGNC VGNC:81082
Mus musculus IL17F MGD MGI:2676631
Felis catus IL17F VGNC VGNC:102442
Canis familiaris IL17F VGNC VGNC:41945
Bos taurus IL17F VGNC VGNC:30121
Macaca fascicularis IL17F NCBI NCBI:102118959
Others IL17F NCBI