Animal-Free IL-30/IL-27A 蛋白, Mouse (His)

The IL-30/IL-27A protein is a component of the Ragulator complex, which is critical for amino acids and activates mTORC1 to regulate cell growth in response to different signals. The lysosomal V-ATPase and Ragulator complex act as GEFs for Rag GTPase, promoting amino acid activation. Animal-Free IL-30/IL-27A Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-30/IL-27A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-30/IL-27A Protein, Mouse (His) is 206 a.a., with molecular weight of ~24.51 kDa.

LAMTOR2 作为 Ragulator 复合物的一个组成部分，在氨基酸传感和 mTORC1 激活中发挥着至关重要的作用，mTORC1 是一种信号复合物，对于细胞生长调节响应各种信号（如生长因子、能量水平和氨基酸）至关重要。溶酶体 V-ATP 酶和 Ragulator 复合物促进氨基酸激活，Ragulator 复合物充当小 GTPases Rag（RagA/RRAGA、RagB/RRAGB、RagC/RRAGC 和/或 RagD/）的鸟嘌呤核苷酸交换因子 (GEF) RRAGD）和将其募集至溶酶体膜的介质。然后，激活的 Ragulator 和 Rag GTPases 充当支架，将 mTORC1 招募到溶酶体以进行后续激活。LAMTOR2 是 Ragulator 复合体的一部分，该复合体还包括 LAMTOR1、LAMTOR3、LAMTOR4 和 LAMTOR5。该复合物与 mTORC1、Rag GTPases 和溶酶体氨基酸传感器 SLC38A9 相互作用。此外，LAMTOR2 参与溶酶体卵泡蛋白复合物 (LFC)，有助于参与生长和营养感知的细胞信号传导途径。

Mouse

E. coli

C-His

Q8K3I6 (F29-S234)

246779  [NCBI]

MFPTDPLSLQELRREFTVSLYLARKLLSEVQGYVHSFAESRLPGVNLDLLPLGYHLPNVSLTFQAWHHLSDSERLCFLATTLRPFPAMLGGLGTQGTWTSSEREQLWAMRLDLRDLHRHLRFQVLAAGFKCSKEEEDKEEEEEEEEEEKKLPLGALGGPNQVSSQVSWPQLLYTYQLLHSLELVLSRAVRDLLLLSLPRRPGSAWDS

Approximately 24.51 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<0.1 EU per 1 μg of the protein by the LAL method.