1. 重组蛋白
  2. Cytokines and Growth Factors Animal-free Recombinant Proteins
  3. Chemokine & Receptors
  4. CXC Chemokines
  5. IP-10/CXCL10
  6. Animal-Free IP-10/CRG-2/CXCL10 蛋白, Mouse (His)

Animal-Free IP-10/CRG-2/CXCL10 蛋白, Mouse (His)

目录号: HY-P700168AF
COA 产品使用指南

IP-10/CRG-2/CXCL10 蛋白是一种促炎细胞因子,可调节免疫细胞、细胞生长、细胞凋亡和血管抑制作用。在病毒感染期间,通过与 CXCR3 结合来激活免疫细胞并将其迁移到感染部位至关重要。Animal-Free IP-10/CRG-2/CXCL10 蛋白, Mouse (His) 是重组的 无动物源 IP-10/CRG-2/CXCL10 蛋白,由 E. coli 表达,带有 N-His 标签。Animal-Free IP-10/CRG-2/CXCL10 蛋白, Mouse (His) 全长 77 个氨基酸,分子量约为 ~9.47 kDa。

无动物成分 (Animal-free) 重组蛋白,即生产过程中不使用或接触任何动物来源的材料和试剂,具有高一致性和稳定性。

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SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 μg ¥2300 In-stock
50 μg ¥5800 In-stock
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

The IP-10/CRG-2/CXCL10 protein is a proinflammatory cytokine that regulates immune cells, cell growth, apoptosis, and vasostatic effects. It is critical during viral infection by binding to CXCR3 to activate immune cells and migrate them to the site of infection. Animal-Free IP-10/CRG-2/CXCL10 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIP-10/CRG-2/CXCL10 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IP-10/CRG-2/CXCL10 Protein, Mouse (His) is 77 a.a., with molecular weight of ~9.47 kDa.

研究背景

IP-10/CRG-2/CXCL10 蛋白是一种促炎细胞因子,参与免疫细胞的趋化、分化和激活等多种过程,以及细胞生长、凋亡的调节和血管抑制的调节影响。它通过刺激免疫细胞的激活和迁移到感染部位,在病毒感染过程中发挥至关重要的作用。从机制上讲,它与 CXCR3 受体结合,激活 G 蛋白介导的信号传导,并导致磷脂酶 C 依赖性途径的激活、细胞内钙的产生增加和肌动蛋白重组。CXCL10/CXCR3 轴的激活对于神经元响应脑损伤也很重要,因为它激活小胶质细胞并将其引导至损伤部位,促进神经元重组。IP-10/CRG-2/CXCL10 蛋白可以单体、二聚体或四聚体形式存在,并与 CXCR3 受体相互作用。

生物活性

Measure by its ability to chemoattract BaF3 cells transfected with human CXCR3. The ED50 for this effect is <0.2 μg/mL

种属

Mouse

表达系统

E. coli

标签

N-His

蛋白编号

P17515 (I22-P98)

基因 ID
蛋白结构
N-term
His
CXCL10 (I22-P98)
Accession # P17515
C-term
中文名
重组小鼠IP-10/CXCL10
同用名
IP-10; Gamma-Interferon Inducible Protein 10; Crg-2
氨基酸序列

IPLARTVRCNCIHIDDGPVRMRAIGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP

分子量

Approximately 9.47 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

内毒素含量

<0.1 EU per 1 μg of the protein by the LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Animal-Free IP-10/CRG-2/CXCL10 Protein, Mouse (His)
目录号:
HY-P700168AF
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