2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules Macrophage CD Proteins
  5. BTLA BTLA/CD272
  6. BTLA/CD272 蛋白, Mouse (HEK293, hFc)

BTLA/CD272 蛋白, Mouse (HEK293, hFc)

目录号: HY-P75467
产品使用指南

BTLA/CD272 蛋白在淋巴细胞上表达，是抗原受体信号传导的负调节因子。它与酪氨酸磷酸酶 PTPN6/SHP-1 和 PTPN11/SHP-2 相互作用，调节免疫反应并维持淋巴细胞稳态。BTLA/CD272 蛋白, Mouse (HEK293, hFc) 是重组的 BTLA/CD272 蛋白，由 HEK293 表达，带有 C-hFc 标签。BTLA/CD272 蛋白, Mouse (HEK293, hFc) 全长 147 个氨基酸，分子量为 57-62 kDa。

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描述

The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTLA/CD272 Protein, Mouse (HEK293, hFc) is 147 a.a., with molecular weight of 57-62 kDa.
研究背景

BTLA/CD272 是淋巴细胞上表达的抑制性受体，通过与酪氨酸磷酸酶 PTPN6/SHP-1 和 PTPN11/SHP-2 相互作用，充当抗原受体信号传导的负调节因子。这些相互作用有助于调节免疫反应和维持淋巴细胞稳态。BTLA 可能与 TNFRSF14 发生顺式和反式相互作用，顺式相互作用在幼稚 T 细胞中发挥调节作用，抑制反式相互作用以维持静息状态。相比之下，在适应性免疫反应期间占主导地位的反式相互作用为效应 T 细胞提供生存信号。BTLA 与其结合伙伴之间错综复杂的相互作用强调了其在免疫调节中的多方面作用。
种属

Mouse
表达系统

HEK293
标签

C-hFc
蛋白编号

Q32MV9 (E30-G176)
基因 ID
蛋白结构
N-term
BTLA (E30-G176)
Accession # Q32MV9
hFc
C-term
同用名
B- and T-lymphocyte attenuator; CD272; BTLA
分子量

57-62 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

BTLA/CD272 Protein, Mouse (HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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