1. 重组蛋白
  2. Complement System
  3. Complement Component 1
  4. C1q
  5. Complement C1q A-Chain (C1QA)
  6. C1QA 蛋白, Mouse (P.pastoris, His)

C1QA 蛋白, Mouse (P.pastoris, His)

目录号: HY-P71718
COA 产品使用指南

C1QA 蛋白有助于形成 C1,它是血清补体系统的起始成分。C1q 与酶原 C1r 和 C1s 结合,导致 C1 组装。C1QA 蛋白, Mouse (P.pastoris, His) 是重组的 C1QA 蛋白,由 P. pastoris 表达,带有 N-6*His 标签。C1QA 蛋白, Mouse (P.pastoris, His) 全长 223 个氨基酸,分子量约为 ~25.6 kDa。

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     可免费申领三个不同产品的试用装。

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5 μg ¥1440 In-stock
10 μg ¥2440 In-stock
50 μg ¥6830 In-stock
100 μg   询价  

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描述

The C1QA protein helps form C1, the starting component of the serum complement system. C1q binds to the zymogens C1r and C1s, resulting in C1 assembly. C1QA Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived C1QA protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of C1QA Protein, Mouse (P.pastoris, His) is 223 a.a., with molecular weight of ~25.6 kDa.

研究背景

C1QA 蛋白在 C1(血清补体系统的起始成分)的形成中起着关键作用。C1q 与酶原 C1r 和 C1s 结合,导致 C1 的组装。C1q 的胶原蛋白样区域与 Ca(2+) 依赖性 C1r(2)C1s(2) 酶原复合物结合,C1q 的球状头与 IgGIgG 的 Fc 区域相互作用时,C1 就会被有效激活。免疫复合物内的 IgM 抗体。活性C1由C1q、C1r和C1s以1:2:2的摩尔比组成的钙依赖性三分子复合物。C1q 亚组分由 9 个亚基组成,其中 6 个亚基形成 A 链和 B 链的二硫键连接的二聚体,其余 3 个形成 C 链的二硫键连接的二聚体。此外,C1QA 通过其 C 末端与 CD33 相互作用,激活 CD33 抑制基序。

种属

Mouse

表达系统

P. pastoris

标签

N-6*His

蛋白编号

P98086 (E23-A245)

基因 ID
蛋白结构
N-term
6*His
C1QA (E23-A245)
Accession # P98086
C-term
同用名
C1qaComplement C1q subcomponent subunit A
氨基酸序列

EDVCRAPNGKDGAPGNPGRPGRPGLKGERGEPGAAGIRTGIRGFKGDPGESGPPGKPGNVGLPGPSGPLGDSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPMTLGNVVIFDKVLTNQESPYQNHTGRFICAVPGFYYFNFQVISKWDLCLFIKSSSGGQPRDSLSFSNTNNKGLFQVLAGGTVLQLRRGDEVWIEKDPAKGRIYQGTEADSIFSGFLIFPSA

分子量

Approximately 25.6 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against solution in 20 mM Tris-HC1, 0.5 M NaCl, 6% Trehalose, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

C1QA Protein, Mouse (P.pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
C1QA Protein, Mouse (P.pastoris, His)
目录号:
HY-P71718
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