Cadherin-6/KCAD 蛋白, Rat (HEK293, His)

Cadherin-6/KCAD Protein, a member of the calcium-dependent cell adhesion protein family, assumes a crucial role in mediating cellular adhesion. It exhibits a preference for interacting with other cadherin molecules of the same type in a homophilic manner, facilitating the adhesion between connecting cells. As a calcium-dependent adhesion protein, Cadherin-6/KCAD participates in maintaining the structural integrity of tissues and regulating cellular processes such as development, differentiation, and morphogenesis. Cadherin-6/KCAD Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-6/KCAD protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-6/KCAD Protein, Rat (HEK293, His) is 597 a.a., with molecular weight of 85-95 KDa.

Cadherin-6/KCAD 是钙依赖性细胞粘附蛋白家族的成员，在介导细胞粘附中发挥着至关重要的作用。它表现出以亲同性方式与相同类型的其他钙粘蛋白分子相互作用的偏好，促进连接细胞之间的粘附。钙粘蛋白这种选择性地与自身相互作用的独特能力有助于组织和器官中异质细胞类型的分类和组织。作为一种钙依赖性粘附蛋白，Cadherin-6/KCAD 参与维持组织的结构完整性并调节发育、分化和形态发生等细胞过程。Cadherin-6 在正常人肾脏近端肾小管中的特异性表达，并表明 Cadherin-6 表达的改变与肾细胞癌的进展有关。此外，Cadherin-6 在血小板表面表达，并且在体内血栓形成中起着重要作用^[1][2]。

Measured by the ability of the immobilized protein to support the adhesion of Caki-2 human clear cell carcinoma epithelial cells. The ED₅₀ for this effect is 0.6536 μg/mL, corresponding to a specific activity is 1529.98 units/mg.

Rat

HEK293

C-10*His

EDL82944 (T19-A615)

/

TFSNPLSKRTSGFPAKRRALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHDMFDVITDQETQEGIITVKKLLDFEKKRVYTLKVEASNPHIEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKLAYILQIREDAQINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGA

Approximately 85-95 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.