CAPG 蛋白, Human

Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca²⁺-sensitive protein and plays a role in macrophage function and is involved in the process of metastasis by promoting the invasiveness of tumor cells^[1][2][3]. CAPG Protein, Human is the recombinant human-derived CAPG protein, expressed by E. coli , with tag free. The total length of CAPG Protein, Human is 348 a.a..

巨噬细胞帽蛋白 (CAPG) 是一种普遍存在的肌动蛋白结合蛋白，属于凝溶胶蛋白/绒毛蛋白超家族，与细胞运动相关。CAPG 是一种 Ca²⁺ 敏感蛋白，在巨噬细胞功能和癌症进展中发挥作用^[1][2]。此外，CapG 在多种癌症中表达含量升高，如肝癌、胰腺癌和乳腺癌。CapG 通过促进肿瘤细胞的侵袭性参与转移过程^[3]。

Human

E. coli

Tag Free

AAH14549 (M1-K348)

822  [NCBI]

MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDWK

Approximately 40 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 200 mM NaCl, pH 8.0, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.