1. Gene
  2. CAPG - capping actin protein, gelsolin like Gene

CAPG - capping actin protein, gelsolin like Gene

中文名称:加帽肌动蛋白,凝溶胶蛋白样

种属: Homo sapiens

同用名: MCP; AFCP; HEL-S-66

基因 ID: 822 | 基因类型: protein coding

关于 CAPG

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,391,602-85,419,540 (from NCBI)

This gene has 15 transcripts (splice variants), 211 orthologues and 7 paralogues. Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues.

功能概要

该基因编码肌动蛋白调节蛋白凝溶胶蛋白/绒毛蛋白家族的成员。编码的蛋白质以 Ca2+ 和磷酸肌醇调节的方式可逆地阻断 F-肌动蛋白丝的倒刺末端,但不会切断预先形成的肌动蛋白丝。通过覆盖肌动蛋白丝的倒刺末端,编码的蛋白质有助于控制非肌肉细胞中基于肌动蛋白的运动。已观察到该基因的可变剪接转录物变体。[RefSeq 提供,2012 年 1 月]

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

CAPG 基因产物(6)

mRNA Protein Name
NM_001256139.2 NP_001243068.1 macrophage-capping protein isoform 1
NM_001256140.2 NP_001243069.1 macrophage-capping protein isoform 2
NM_001320732.2 NP_001307661.1 macrophage-capping protein isoform 1
NM_001320733.2 NP_001307662.1 macrophage-capping protein isoform 1
NM_001320734.2 NP_001307663.1 macrophage-capping protein isoform 3
NM_001747.4 NP_001738.2 macrophage-capping protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18266911 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
18266911 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
18266911 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in extracellular matrix disassembly IMP
IMP: 通过突变表型推断
24236012 GOA
NOT involved in positive regulation of podosome assembly IMP
IMP: 通过突变表型推断
24236012 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Flemming body IDA
IDA: 通过直接分析推断
19166812 GOA
located in centriole IDA
IDA: 通过直接分析推断
19166812 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18266911 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
19166812 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
18938132 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
18938132 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18266911 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

macrophage-capping protein

actin-regulatory protein CAP-G

CAPG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CAPG P40121 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra CAPG P40121 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra CAPG P40121 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CAPG 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75601 CAPG Protein, Human AAH14549 (M1-K348) ≥95%

直系同源

种属 基因名 来源 基因 ID
Bos taurus CAPG VGNC VGNC:26739
Canis familiaris CAPG VGNC VGNC:38697
Macaca mulatta CAPG VGNC VGNC:70528
Rattus norvegicus CAPG RGD RGD:1311724
Felis catus CAPG VGNC VGNC:80045
Mus musculus CAPG MGD MGI:1098259
Others CAPG NCBI