Cardiotrophin-1/CTF1 蛋白, Human (His)

Cardiotrophin-1/CTF1 Protein, Human (His) is an approximately 25.0 kDa human cardiotrophin-1 protein with a His-flag. Cardiotrophin-1belongs to the IL-6 family and can act as a cytoprotective molecule^[1].

心肌营养素-1 (CT-1) 是 IL-6 家族的新成员，该家族还包括 IL-6、IL-11、白血病抑制因子 (LIF)、制瘤素 M (OSM) 和睫状神经营养因子 (CNTF)< super>[1]。
Cardiotropin-1 通过共享信号亚基 gp 130^[2] 诱导其生物效应。
人类 CT-1 编码缺乏疏水信号肽的 201 个氨基酸 (aa) 残基蛋白质。人类和小鼠 CT-1 具有 80% 的 aa 序列同一性，并表现出跨物种活性。CT-1在心脏、骨骼肌、肝脏、肺和肾脏中高表达。睾丸和大脑中也存在较低水平的 CT-1 表达^[2]。
CT-1 通过 gp130 和 LIF 受体 β 亚基的异二聚化启动下游信号传导通路。第三个α受体亚基与受体复合物有关。Cardiotropin-1 可充当细胞保护分子。
重组人 Cardiotropin-1，His 是一种大约 25.0 kDa 的人 Cardiotropin-1 蛋白，带有 His 标记。Cardiotropin-1 属于 IL-6 家族，可充当细胞保护分子^[1]。

Human

E. coli

N-6*His

Q16619 (M1-A201)

1489  [NCBI]

HHHHHHMSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA

Approximately 25.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. O Robledo, et al. Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component. J Biol Chem. 1997 Feb 21;272(8):4855-63.  [Content Brief]

  [2]. D Pennica, et al. Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. Cytokine Growth Factor Rev. 1996 Jun;7(1):81-91.  [Content Brief]

  [3]. Miguel López-Yoldi, et al. Cardiotrophin-1: A multifaceted cytokine. Cytokine Growth Factor Rev. 2015 Oct;26(5):523-32.  [Content Brief]