CCR5 蛋白, Human (HEK293, Flag, His, Strep)

CCR5 Protein, a receptor for inflammatory CC-chemokines like CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, transduces signals, elevating intracellular calcium levels. It regulates granulocytic lineage and facilitates T-lymphocyte migration to infection sites. In microbial infection, CCR5 acts as a coreceptor, along with CD4, for HIV-1, emphasizing its role in the cellular response to infections. CCR5 Protein, Human (HEK293, Flag, His, Strep) is the recombinant human-derived CCR5 protein, expressed by HEK293 Cell-free , with N-Flag, C-His, C-Strep labeled tag.

CCR5 作为多种炎症性 CC 趋化因子（包括 CCL3/MIP-1-alpha、CCL4/MIP-1-beta 和 RANTES）的受体发挥作用，导致信号转导，从而提高细胞内钙离子水平。该受体参与粒细胞谱系增殖或分化的调节，并作为趋化受体在促进 T 淋巴细胞迁移至感染部位方面发挥着至关重要的作用。在微生物感染的情况下，CCR5 充当人类免疫缺陷病毒-1/HIV-1 的辅助受体，CD4 是主要受体，强调了其在细胞对感染反应中的重要性。

Immobilized Recombinant Human CCR5-Detergent Protein at 5 μg/mL (100 μL/well) on Nickel coated plate can bind Anti-CCR5 Monoclonal Antibody, human IgG1, the EC₅₀ is 1.5-5 ng/mL.

Human

HEK293

C-His;N-Flag;C-Strep

P51681 (M1-R319, thermostabilizing mutations)

1234

43.96 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, 0.02% DDM, 0.004% CHS, 5% Glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.