2. 重组蛋白
  3. CAR-T related Proteins CD Antigens
  4. T Cell CD Proteins B Cell CD Proteins Stem Cell CD Proteins
  5. CD38
  6. CD38 蛋白, Rat (HEK293, Fc)

CD38 蛋白, Rat (HEK293, Fc)

目录号: HY-P72897
产品使用指南

CD38 蛋白发挥多种作用，合成关键的第二信使：用于葡萄糖诱导胰岛素分泌的环 ADP-核糖 (cADPR) 和作为钙动员剂的烟酸腺嘌呤二核苷酸磷酸 (NAADP)。其 cADPR 水解酶活性增加了其多功能性。值得注意的是，CD38 还可能通过产生 cADPR 并通过兰尼碱受体激活启动钙离子信号来调节破骨细胞骨吸收。CD38 蛋白, Rat (HEK293, Fc) 是重组的 CD38 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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规格 是否有货
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100 μg   询价  

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描述

CD38 protein plays diverse roles, synthesizing key second messengers: cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion and nicotinate-adenine dinucleotide phosphate (NAADP) as a calcium mobilizer.Its cADPR hydrolase activity adds to its versatility.Notably, CD38 also regulates osteoclastic bone resorption, likely by producing cADPR and initiating a calcium ion signal through ryanodine receptor activation.CD38 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

CD38 蛋白执行多种重要功能。它负责合成两个重要的第二信使，环状ADP-核糖和烟酸-腺嘌呤二核苷酸磷酸。环状 ADP-核糖充当葡萄糖诱导的胰岛素分泌的第二信使，而烟酸-腺嘌呤二核苷酸磷酸则充当钙动员剂。CD38 还具有 cADPR 水解酶活性，从而增强了其功能。此外，CD38 调节破骨细胞的骨吸收，最有可能是通过产生环状 ADP-核糖并通过激活兰尼碱受体启动钙离子信号。
种属

Rat
表达系统

HEK293
标签

C-hFc
蛋白编号

Q64244 (W45-V303)
基因 ID
蛋白结构
N-term
CD38 (W45-V303)
Accession # Q64244
hFc
C-term
同用名
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; ADPRC 1; CD38
氨基酸序列

WPRSPLVWKGKPTTKHFADIILGRCLIYTQILRPEMRDQDCKKILSTFKRGFISKNPCNITNEDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYDSCPHWSENCPNNPVAVFWNVISQKFAEDACGVVQVMLNGSLSEPFYRNSTFGSVEVFNLDPNKVHKLQAWVMHDIKGTSSNACSSPSINELKSIVNKRNMIFACQDNYRPVRFLQCVKNPEHPSCRLNV

分子量

Approximately 67 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD38 Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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