2. Gene
  3. Cd38 - CD38 molecule Gene

Cd38 - CD38 molecule Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：CD38 分子

种属: Rattus norvegicus

同用名: ADPRC 1

基因 ID: 25668 | 基因类型: protein coding

关于 Cd38

Primary_assembly 14: 67,172,063-67,211,986 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 281 orthologues, 1 paralogue and is associated with 8 phenotypes. Biased expression in Spleen (RPKM 249.7), Lung (RPKM 118.2) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 NAD+ 核苷酶活性。参与多个过程，包括维持血管直径；长期突触抑制；和骨吸收的负调节。位于基底外侧质膜；核;和分泌颗粒膜。 2 型糖尿病的生物标志物。该基因的人类直系同源物与 1 型糖尿病和 2 型糖尿病有关。与人 CD38（CD38 分子）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd38 基因产物(1)

mRNA Protein Name
NM_013127.2 NP_037259.1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+ nucleotidase, cyclic ADP-ribose generating IDA
IDA: 通过直接分析推断
11733184 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in artery smooth muscle contraction IMP
IMP: 通过突变表型推断
21431168 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
14998907 RGD
involved in long-term synaptic depression IMP
IMP: 通过突变表型推断
10097163 RGD
involved in negative regulation of bone resorption IDA
IDA: 通过直接分析推断
10477767 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
19696022 RGD
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
18719074 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
19696022 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
18719074 RGD
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
9664081 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
18524860 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
11399650 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
14998907 RGD
involved in response to hormone IDA
IDA: 通过直接分析推断
9325179 RGD
involved in response to hydroperoxide IDA
IDA: 通过直接分析推断
12893282 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
12111041 RGD
involved in response to interleukin-1 IEP
IEP: 通过表达模式推断
11399650 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
14998907 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
11399650 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
21784055 RGD
located in nuclear membrane IDA
IDA: 通过直接分析推断
11733184 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cd38 蛋白结构

Rib_hydrolayse

Rib_hydrolayse: pfam02267 (57 - 286)

  • 0
  • 100
  • 200
  • 303 a.a.
蛋白主名 其他名称

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

2'-phospho-ADP-ribosyl cyclase

2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

2'-phospho-cyclic-ADP-ribose transferase

ADP-ribosyl cyclase 1

CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)

CD38H

cADPr hydrolase 1

cyclic ADP-ribose hydrolase 1

重组 Cd38 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70077 CD38 Protein, Rat (HEK293, His) Q64244 (W45-V303) ≥95%
HY-P72897 CD38 Protein, Rat (HEK293, Fc) Q64244 (W45-V303) ≥95%

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P9915 Daratumumab 99.00% 否
Clinical Phase
抗体抑制剂 (5)
目录号 产品名 作用方式
纯度 Phase
HY-P9915A Daratumumab (PBS) ≥95.0% Phase 4
HY-P9976A Isatuximab (anti-CD38) 98.44% Phase 3
HY-P99730 Mezagitamab Inhibitor 99.76% Phase 2
HY-P99616 Felzartamab Inhibitor 99.34% Phase 2
HY-P99744 Modakafusp alfa Inhibitor 96.22% Phase 2
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123999 CD38 inhibitor 1 99.83% 否
HY-N0640 Kuromanin chloride Inhibitor 99.50% 否
HY-150508 MK-0159 Inhibitor 99.72% 否
HY-144987 RBN013209 98.87% 否
HY-129997 Luteolinidin chloride Inhibitor 99.14% 否
HY-134358A Ara-F-NAD+ sodium Inhibitor 99.81% 否
HY-156120 CD38 inhibitor 3 Inhibitor 98.39% 否
HY-144988 CD38 inhibitor 2 98.81% 否
HY-134358 Ara-F-NAD+ Inhibitor / 否
HY-P10563 Noraramtide / 否
HY-119648A (E/Z)-CCR-11 Inhibitor 98.00% 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990037 Erzotabart Inhibitor / 否
HY-P990747 Lumrotatug Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd38 NCBI NCBI:952
Macaca fascicularis Cd38 NCBI NCBI:102126394
Mus musculus Cd38 NCBI NCBI:12494
Leporidae Cd38 NCBI
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