Cd38 - CD38 antigen Gene

中文名称：CD38 抗原

种属: Mus musculus

同用名: I-19; ADPRC 1; Cd38-rs1

关于 Cd38

功能概要

该基因编码一种非谱系限制的 II 型跨膜糖蛋白，可合成和水解环腺苷 5'-二磷酸核糖，一种细胞内钙离子动员信使。可溶性蛋白的释放和膜结合蛋白内化的能力表明了该蛋白的细胞外和细胞内功能。该蛋白有一个 N 端胞质尾部、一个跨膜结构域和一个带有四个 N 糖基化位点的 C 端胞外区。该基因缺陷的基因敲除小鼠表现出改变的体液免疫反应。此外，敲除小鼠表现出更高的运动活性以及在养育和社交行为方面的缺陷。 [RefSeq 提供，2015 年 9 月]

This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]