CD59a 蛋白, Mouse (HEK293, Fc)

CD59a Protein acts as a potent inhibitor of the complement membrane attack complex (MAC) by binding to C8 and/or C9 complements during MAC assembly. This interaction prevents the incorporation of multiple C9 copies, crucial for osmolytic pore formation. CD59a's regulatory role at the MAC assembly level safeguards cells, preventing uncontrolled osmolytic pore formation and protecting against complement-mediated damage. CD59a Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD59a protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD59a Protein, Mouse (HEK293, Fc) is 72 a.a., with molecular weight of ~42 kDa.

CD59a 蛋白是补体膜攻击复合物 (MAC) 作用的有效抑制剂，通过在 MAC 组装过程中与 C8 和/或 C9 补体结合发挥作用。通过这种相互作用，CD59a 阻止了渗透孔完全形成所必需的 C9 多个拷贝的掺入。这种调节作用强调了 CD59a 在调节补体系统中的关键贡献，特别是在 MAC 组装水平上，并作为防止渗透孔不受控制形成的关键保护机制，最终保护细胞免受潜在的补体介导的损伤。

Mouse

HEK293

C-hFc

O55186/NP_001104530.1 (L24-K95)

12509  [NCBI]

LTCYHCFQPVVSSCNMNSTCSPDQDSCLYAVAGMQVYQRCWKQSDCHGEIIMDQLEETKLKFRCCQFNLCNK

Approximately 42 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.