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  4. CDK19-CCNC 蛋白, Human (sf9, GST)

CDK19-CCNC 蛋白, Human (sf9, GST)

目录号: HY-P702907
产品使用指南 技术支持

CDK19 在细胞稳态和发育编程中发挥着关键作用。CDK19 可与 p53 相互作用,抑制 p53 介导的 p21 转录,调节造血干细胞和急性髓性白血病细胞的增殖。此外,CDK19CDK8 的旁系同源物。CDK8CDK19 可以相互配合支持白血病细胞生长、刺激 NFκB 诱导的转录和登革热病毒复制。CDK19-CCNC 蛋白, Human (sf9, GST) 是重组的 CDK19-CCNC 蛋白,由 Sf9 insect cells 表达,带有 N-GST 标签。CDK19-CCNC 蛋白, Human (sf9, GST)

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描述

CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication[1][2][3]. CDK19-CCNC Protein, Human (sf9, GST) is the recombinant human-derived CDK19-CCNC, expressed by Sf9 insect cells , with N-GST labeled tag. ,

研究背景

CDK19CDK8 的旁系同源物。CDK19 在细胞稳态和发育编程中发挥着关键作用[1]CDK19 可与 p53 相互作用,抑制 p53 介导的 p21 转录,调节造血干细胞和急性髓性白血病细胞的增殖[2]。此外,CDK8CDK19 可以相互配合支持白血病细胞生长、刺激 NFκB 诱导的转录和登革热病毒复制[3]

种属

Human

表达系统

Sf9 insect cells

标签

N-GST

蛋白编号

Q9BWU1-1 (M1-Y502)&P24863-1 (M1-S283)

基因 ID

23097

同用名
CDC2L6; CDK11; KIAA1028
分子量

CDK19: 92 kDa; CCNC: 55 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CDK19-CCNC Protein, Human (sf9, GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CDK19-CCNC Protein, Human (sf9, GST)
目录号:
HY-P702907
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