CEBP gamma/CEBPG 蛋白, Human (His)

CEBP gamma/CEBPG protein is a transcription factor that regulates genes by binding to their promoter and enhancer regions. It targets IL-4 and immunoglobulin heavy chains, binding to enhancer elements PRE-I and GPE1 in the G-CSF gene promoter. CEBP gamma/CEBPG Protein, Human (His) is the recombinant human-derived CEBP gamma/CEBPG protein, expressed by E. coli , with N-His labeled tag. The total length of CEBP gamma/CEBPG Protein, Human (His) is 109 a.a., with molecular weight of ~16 kDa.

CEBP gamma/CEBPG 蛋白作为转录因子发挥作用，通过与靶基因的启动子和增强子区域结合来发挥其调节影响。它特异性结合 IL-4 基因的增强子元件 PRE-I（正调控元件-I），以及免疫球蛋白重链的启动子和增强子区域。此外，CEBP gamma/CEBPG 与 GPE1（G-CSF 基因启动子中的顺式作用元件）结合。其 DNA 结合以二聚体形式发生，并且能够与 CEBPA 和 CEBPB 形成稳定的异二聚体，这凸显了其多功能的相互作用特征。此外，CEBP gamma/CEBPG 与 ZNF638 相互作用，这种相互作用有助于增加转录激活，进一步凸显其在调节基因表达中的作用。

Human

E. coli

N-His

P53567 (P39-N147)

1054  [NCBI]

PGGGGKAVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDN

Approximately 16 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.