CELA2A 蛋白, Human (His)

The function of the CELA2A protein as elastase goes beyond its traditional role as it not only enhances insulin signaling but also appears to play a potential physiological role in cellular glucose metabolism. This multifaceted protein circulates in the plasma and exerts regulatory effects by reducing platelet overactivation. CELA2A Protein, Human (His) is the recombinant human-derived CELA2A protein, expressed by E. coli , with N-6*His labeled tag. The total length of CELA2A Protein, Human (His) is 241 a.a., with molecular weight of ~29.9 kDa.

CELA2A 被认为是一种弹性蛋白酶，在细胞葡萄糖代谢和胰岛素信号传导中具有独特的作用。已知这种蛋白质在血浆中循环，在调节血小板过度活化中发挥关键作用。CELA2A 对胰岛素动力学具有双重影响，既能触发胰岛素分泌，又能促进其降解。值得注意的是，弹性蛋白酶可增强胰岛素敏感性，强调其在葡萄糖稳态中的潜在生理意义。CELA2A 的多方面作用凸显了其在胰岛素信号传导、血小板功能和细胞葡萄糖代谢调节中的复杂参与。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

P08217 (V29-N269)

63036  [NCBI]

VVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN

Approximately 29.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.