2. Gene
  3. CELA2A - chymotrypsin like elastase 2A Gene

CELA2A - chymotrypsin like elastase 2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胰凝乳蛋白酶样弹性蛋白酶 2A

种属: Homo sapiens

同用名: PE-1; AOMS4; ELA2A

基因 ID: 63036 | 基因类型: protein coding

关于 CELA2A

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:15,456,732-15,472,091 (from NCBI)

This gene has 3 transcripts (splice variants), 289 orthologues, 6 paralogues and is associated with 1 phenotype. Restricted expression toward pancreas (RPKM 18580.0).

功能概要

弹性蛋白酶形成丝氨酸蛋白酶的一个亚家族，除了弹性蛋白之外，它还能水解许多蛋白质。人类有六个弹性蛋白酶基因，它们编码结构相似的蛋白质弹性蛋白酶 1、2、2A、2B、3A 和 3B。与大多数人类弹性蛋白酶一样，弹性蛋白酶 2A 作为酶原从胰腺分泌。在其他物种中，已显示弹性蛋白酶 2A 优先切割亮氨酸、甲硫氨酸和苯丙氨酸残基后的蛋白质。[RefSeq 提供，2009 年 5 月]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, Elastase 2A is secreted from the pancreas as a zymogen. In other species, Elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]

CELA2A 基因产物(1)

mRNA Protein Name
NM_033440.3 NP_254275.1 chymotrypsin-like elastase family member 2A preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IDA
IDA: 通过直接分析推断
31358993 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
31358993 GOA
enables serine hydrolase activity IDA
IDA: 通过直接分析推断
20179351 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in insulin catabolic process IDA
IDA: 通过直接分析推断
31358993 GOA
involved in regulation of insulin secretion IDA
IDA: 通过直接分析推断
31358993 GOA
involved in regulation of platelet aggregation IDA
IDA: 通过直接分析推断
31358993 GOA
involved in response to insulin IDA
IDA: 通过直接分析推断
31358993 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
31358993 GOA
located in keratohyalin granule IDA
IDA: 通过直接分析推断
20179351 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CELA2A 蛋白结构

Trypsin

Trypsin: Trypsin (29 - 262)

  • 0
  • 100
  • 200
  • 269 a.a.
蛋白主名 其他名称

chymotrypsin-like elastase family member 2A

chymotrypsin like elastase family member 2A

重组 CELA2A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72135 CELA2A Protein, Human (His) P08217 (V29-N269) ≥95%

关联疾病

疾病名称 别名
Abdominal Obesity-Metabolic Syndrome 4

AOMS4
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
Hypertriglyceridemia 1

Hypertriglyceridemia

Hypertriglyceridemia, Familial

Hypertriglyceridemia, Susceptibility To

HYTG1

FHTR

Hypertriglyceridemias Familial
Lipodystrophy, Familial Partial, Type 6

FPLD6

Lipe-Related Familial Partial Lipodystrophy

Familial Partial Lipodystrophy Type 6

Lipe-Related Fpld

Lipodystrophy, Familial Partial, Associated With Lipe Mutations

Familial Partial Lipodystrophy Associated With Lipe Mutations

Lipodystrophy, Familial Partial, 6
Diabetes Mellitus

Diabetes
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Type 1 Diabetes Mellitus 10

Diabetes Mellitus, Insulin-Dependent, 10

IDDM10

Insulin-Dependent Diabetes Mellitus 10

Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10

T1D10

Diabetes, Mellitus, Insulin-Dependent 10

Diabetes Mellitus, Insulin-Dependent, Type 10
Celery Allergy
Type 1 Diabetes Mellitus 11

Diabetes Mellitus, Insulin-Dependent, 11

Iddm11

Insulin-Dependent Diabetes Mellitus 11

T1D11

Insulin-Dependent Diabetes Mellitus-11
Netherton Syndrome

NETH

Ns

Netherton Disease

Comel-Netherton Syndrome

Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

Bamboo Hair Syndrome

Ichthyosis Linearis Circumflexa

Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

Ilc

Nts

N Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02456 CELA2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CELA2A MGD MGI:95316
Rattus norvegicus CELA2A RGD RGD:2548
Others CELA2A NCBI
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