CL-P1/COLEC12 蛋白, Rat (sf9, His)

CL-P1/COLEC12 is a multifunctional scavenger receptor that effectively defends against microorganisms and promotes their binding and phagocytosis, covering Gram-positive and Gram-negative bacteria and yeast. In addition, it mediates the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. CL-P1/COLEC12 Protein, Rat (sf9, His) is the recombinant rat-derived CL-P1/COLEC12 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of CL-P1/COLEC12 Protein, Rat (sf9, His) is 642 a.a., with molecular weight of ~90 KDa.

CL-P1/COLEC12 是一种多方面的清道夫受体，通过促进各种微生物（包括革兰氏阳性菌、革兰氏阴性菌以及酵母）的结合和吞噬作用，在宿主防御中发挥着至关重要的作用。此外，它还作为血管内皮细胞识别、内化和降解氧化修饰低密度脂蛋白 (oxLDL) 的关键介质。该受体表现出多种碳水化合物结合能力，以钙依赖性方式与 Gal 型配体、D-半乳糖、L-和 D-岩藻糖、GalNAc、T 和 Tn 抗原相互作用。具体来说，它将 GalNAc 内化到护士样细胞中，并与唾液酸 Lewis X（一种三糖）和脱唾液酸类唾液酸 (ASOR) 结合。值得注意的是，CL-P1/COLEC12 的胞外结构域形成稳定的三聚体，并与纤维状淀粉样蛋白-β 肽相互作用，表明其可能参与与淀粉样蛋白-β 病理学相关的过程。

Rat

Sf9 insect cells

N-His

Q4V885 (A101-L742)

361289  [NCBI]

Approximately 90 kDa.

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 300 mM NaCl, 10% glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.