2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens Biotinylated Proteins
  4. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins
  5. CTLA-4 CTLA-4
  6. CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His)

CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His)

目录号: HY-P75317
产品使用指南

CTLA-4 是一种关键的抑制性受体，在免疫调节中充当 T 细胞反应的主要负调节因子。其独特的性质是其与B7配体（CD80/CD86）的亲和力明显高于CD28。CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His) 是重组的 CTLA-4 蛋白，由 HEK293 表达，带有 C-His 标签。CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His) 全长 127 个氨基酸，分子量约为 ~15.3 kDa。

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描述

CTLA-4 is a key inhibitory receptor that serves as a major negative regulator of T cell responses in immune regulation. Its unique property is that its affinity to B7 ligands (CD80/CD86) is significantly higher than that of CD28. CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived CTLA-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) is 127 a.a., with molecular weight of ~15.3 kDa.
研究背景

CTLA-4 是一种关键的抑制性受体，在 T 细胞反应中充当主要负调节因子，在复杂的免疫调节网络中发挥影响力。这种调节功能源于 CTLA-4 的独特特性，与同源刺激辅助受体 CD28 相比，CTLA-4 对其天然 B7 家族配体 CD80 和 CD86 的亲和力显着增强。CTLA-4 的同二聚体结构通过二硫键错综复杂地连接，强调了其在免疫调节中作为分子哨兵的作用。从功能上讲，CTLA-4 与 CD80/B7-1 和 CD86/B7.2 紧密结合，竞争性地与这些配体结合，抑制 T 细胞激活并微调免疫反应。此外，CTLA-4 与 ICOSLG 相互作用，有助于其在免疫检查点通路中的多方面参与。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

P09793 (E36-F162)
基因 ID
蛋白结构
N-term
CTLA-4 (E36-F162)
Accession # P09793
His
C-term
同用名
Cytotoxic T-lymphocyte associated protein 4; CTLA4; CD152
分子量

Approximately 15.3 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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