2. Gene
  3. Ctla4 - cytotoxic T-lymphocyte-associated protein 4 Gene

Ctla4 - cytotoxic T-lymphocyte-associated protein 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞毒性 T 淋巴细胞相关蛋白 4

种属: Mus musculus

同用名: Cd152; Ly-56; Ctla-4

基因 ID: 12477 | 基因类型: protein coding

关于 Ctla4

Chromosome 1: 60,926,159-60,954,991 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 157 orthologues, 1 paralogue and is associated with 34 phenotypes. Biased expression in thymus adult (RPKM 1.4), spleen adult (RPKM .8) and 6 other tissues.

功能概要

该基因是免疫球蛋白超家族的成员，编码的蛋白质可作为 T 细胞反应的负调节因子。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2013 年 8 月]

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Ctla4 基因产物(2)

mRNA Protein Name
NM_001281976.1 NP_001268905.1 cytotoxic T-lymphocyte protein 4 isoform 2 precursor
NM_009843.4 NP_033973.2 cytotoxic T-lymphocyte protein 4 isoform 1 precursor
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
16227984 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ctla4 蛋白结构

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 152)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 59)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 41)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (44 - 47)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (51 - 59)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (60 - 67)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (68 - 75)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (68 - 74)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (75 - 96)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (79 - 88)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (93 - 96)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (102 - 131)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (102 - 107)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (110 - 116)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (124 - 131)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (132 - 138)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (139 - 152)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (139 - 151)

  • 0
  • 100
  • 200
  • 223 a.a.
蛋白主名 其他名称

cytotoxic T-lymphocyte protein 4

CD152 antigen

cytotoxic T-lymphocyte-associated antigen 4

重组 Ctla4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70706 CTLA-4 Protein, Mouse (HEK293, Fc) P09793 (A37-D161) ≥95%
HY-P71991 CTLA-4 Protein, Mouse (HEK293, His) P09793 (A37-D161) ≥95%
HY-P75317 CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) P09793 (E36-F162) ≥95%

相关产品

Approval
抗体抑制剂 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P9901 Ipilimumab Inhibitor 99.88% 否
HY-108829 Abatacept ≥99.0% 否
HY-P9918 Tremelimumab 99.50% 否
Clinical Phase
抗体抑制剂 (10)
目录号 产品名 作用方式
纯度 Phase
HY-P99117 Cadonilimab Inhibitor 99.29% Phase 3
HY-P99484 Botensilimab Inhibitor 97.18% Phase 3
HY-P990042 Gotistobart Inhibitor 98.00% Phase 3
HY-P99540 Tuvonralimab Inhibitor 99.14% Phase 3
HY-P99166 Vudalimab Inhibitor ≥99.0% Phase 2
HY-P99514 Zalifrelimab Inhibitor 98.28% Phase 2
HY-P99809 Quavonlimab Inhibitor ≥99.0% Phase 2
HY-P99714 Lorigerlimab Inhibitor / Phase 2
HY-P99760 Nurulimab Inhibitor 95.00% Phase 1
HY-P99844 Davoceticept / Phase 1
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03299 CTLA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03300 Ctla4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03301 Ctla4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99132 Anti-Mouse CTLA-4 Antibody (9D9) ≥98.0% 否
HY-108829A Abatacept (powder) Inhibitor 95.00% 否
HY-P990041 Firastotug Inhibitor / 否
HY-P990048 Muzastotug Inhibitor 99.48% 否
HY-P990703 Porustobart / 否
HY-P99354 Bavunalimab / 否
HY-P99943 Erfonrilimab / 否
HY-P990080 Sovipostobart Inhibitor / 否
HY-P990690 Volrustomig / 否
HY-P990722 Danvilostomig / 否
HY-P990739 Evalstotug / 否
HY-P990775 Vilastobart / 否
HY-P990945 Tazlestobart / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ctla4 NCBI NCBI:1493
Canis familiaris Ctla4 NCBI NCBI:403696
Macaca fascicularis Ctla4 NCBI NCBI:102115124
Rattus norvegicus Ctla4 NCBI NCBI:63835
Macaca mulatta Ctla4 NCBI NCBI:705673
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