1. Immunology/Inflammation
  2. PD-1/PD-L1 CTLA-4
  3. Tuvonralimab

Tuvonralimab  (Synonyms: 托沃瑞利单抗; PSB-205; QL1706 (iparomlimab/tuvonralimab); PBS105)

目录号: HY-P99540 纯度: 99.14%
COA

Tuvonralimab (PSB-205; QL1706) 是一种双重免疫检查点阻断剂,包含有抗 PD-1 IgG4 和抗 CTLA-4 IgG1 抗体、Iparomlimab 和 Tuvonralimab。

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CAS No. : 2417649-44-4

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规格 价格 是否有货 数量
1 mg ¥3500
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5 mg ¥9000
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tuvonralimab (PSB-205; QL1706) is a dual immune checkpoint blockade containing a mixture of anti-PD-1 IgG4 and anti-CTLA-4 IgG1 antibodies, Iparomlimab and Tuvonralimab[1].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Humanized

体外研究
(In Vitro)

Tuvonralimab 包含重链和轻链配对的突变 (HC 突变 K147D/F170C/V173C/C220G/R255K/D399R/K409E;轻链突变 S131K/Q160C/S162C/C214S),但不用于产生双特异性抗体。最终的药物物质是两种单特异性 IgG 的混合物,即 Iparomlimab 和 Tuvonralimab。这两种抗体由同一细胞系产生,Tuvonralimab 内的突变确保了正确链的有效配对。Iparomlimab 不包含突变[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

托沃瑞利单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tuvonralimab
目录号:
HY-P99540
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