2. Immunology/Inflammation
  3. PD-1/PD-L1 CTLA-4
  4. Lorigerlimab

Lorigerlimab  (Synonyms: 洛瑞格利单抗; MGD019)

目录号: HY-P99714

摩尔计算器

Lorigerlimab (MGD019) 是一种双特异性 IgG4 双亲和力再靶向抗体 (DART)。Lorigerlimab 可以阻断 PD-1 和 CTLA-4，并改善 T 细胞反应。Lorigerlimab 可用于转移性去势抵抗性前列腺癌 (mCRPC) 的研究

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CAS No. : 2416595-46-3

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Lorigerlimab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lorigerlimab (MGD019) is a bispecific IgG4 dual-affinity re-targeting antibody (DART). Lorigerlimab can block PD-1 and CTLA-4, and improves T-cell responses. Lorigerlimab can be used for research of metastatic castration-resistant prostate cancer (mCRPC)[1][2][3].

同型

[V-kappa'-VH-h-CH2-CH3_V-kappa-VH']2
种属

Humanized
体外研究
(In Vitro)

Lorigerlimab (0.01 nM-1 nM) 与 Jurkat/PD-1 细胞结合并阻断 PD-L1 与细胞结合[2]。
Lorigerlimab 可以独立地参与和阻断表达一种或另一种检查点分子的细胞上的 PD-1 和 CTLA-4 (EC50: PD-1+ 细胞为 0.42 nM，CTLA-4+ 细胞为 4.8 nM, PD-1 和 CTLA-4+ 细胞为 0.013 nM)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lorigerlimab 相关抗体:
体内研究
(In Vivo)

Lorigerlimab (75 mg/kg，静脉注射) 在食蟹猴中显示出 CTLA-4 阻断作用[2]。
Lorigerlimab (10-100 mg/kg，静脉注射，4 周) 在食蟹猴中耐受性良好，半衰期约为 7 天[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys [4]
Dosage: 75 mg/kg
Administration: i.v.
Result: Increased the Ki67+ T cell fraction, and showed T cell expansion in the spleen.
Clinical Trial
CAS 号
中文名称

洛瑞格利单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [V-kappa'-VH-h-CH2-CH3_V-kappa-VH']2
纯度 & 产品资料
参考文献

Lorigerlimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lorigerlimab2416595-46-3MGD019洛瑞格利单抗MGD 019MGD-019PD-1/PD-L1CTLA-4PD-1/Programmed death-ligand 1Cytotoxic T-lymphocyte-associated protein 4CD152DARTPD-1T-cellmCRPCprostate cancerInhibitorinhibitorinhibit

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