1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CXC Chemokines
  5. CXCL17
  6. CXCL17 蛋白, Human

CXCL17 蛋白, Human

目录号: HY-P71878
产品使用指南

CXCL17 蛋白是一种趋化因子,可吸引单核细胞、巨噬细胞和树突状细胞,并在血管生成和潜在肿瘤发展中发挥作用。CXCL17 蛋白, Human 是重组的 CXCL17 蛋白,由 E. coli 表达,不带标签。CXCL17 蛋白, Human 全长 98 个氨基酸,分子量约为 ~11.5 kDa。

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描述

The CXCL17 protein is a chemokine that attracts monocytes, macrophages, and dendritic cells and plays a role in angiogenesis and potential tumor development. CXCL17 Protein, Human is the recombinant human-derived CXCL17 protein, expressed by E. coli , with tag free. The total length of CXCL17 Protein, Human is 98 a.a., with molecular weight of ~11.5 kDa.

研究背景

各种研究表明,CXCL17 蛋白作为一种趋化因子,对单核细胞、巨噬细胞和树突状细胞具有趋化特性。它的参与延伸到血管生成和潜在的肿瘤发展,强调了它在复杂的生理过程中的作用。在胃中,CXCL17 充当抗炎剂,有助于局部免疫调节。此外,有人认为 CXCL17 可能参与针对感染的先天防御,从而扩大了其在免疫反应中的重要性。通过与 CXC 趋化因子受体 GPR35 的相互作用,CXCL17 诱导细胞内钙离子快速且短暂的增加,为其信号传导机制增加了一层特异性。值得注意的是,与 6-Cys CXCL17 相比,CXCL17 对单核细胞和巨噬细胞表现出显着更高的化学引诱效力,强调了其独特的功能特征。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q6UXB2 (S22-L119)

基因 ID
蛋白结构
N-term
CXCL17 (S22-119L)
Accession # Q6UXB2
C-term
同用名
CXCL17; VCC1; UNQ473/PRO842C-X-C motif chemokine 17; 6-Cys CXCL17; Dendritic cell and monocyte chemokine-like protein; DMC; VEGF coregulated chemokine 1; 4-Cys CXCL17
氨基酸序列

SSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL

分子量

Approximately 11.5 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CXCL17 Protein, Human
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