DDR1 蛋白, Mouse (HEK293, Fc)

DDR1 Protein, a fibrillar collagen receptor, orchestrates critical cellular processes, including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates a signaling cascade involving SRC and MAP kinases, contributing to matrix remodeling through MMP up-regulation, facilitating cell migration, wound healing, and tumor invasion. DDR1 also aids arterial wound healing, phosphorylates PTPN11, and is vital for blastocyst implantation, mammary gland differentiation, lactation, and ear morphology maintenance. Its multifunctional role underscores DDR1's significance in governing diverse physiological processes. DDR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived DDR1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of DDR1 Protein, Mouse (HEK293, Fc) is 414 a.a., with molecular weight of 80-90 kDa.

DDR1 蛋白是一种酪氨酸激酶，作为纤维胶原蛋白的细胞表面受体，协调对组织稳态至关重要的多种细胞过程。它调节细胞与细胞外基质的附着，影响基质重塑、细胞迁移、分化、存活和增殖。胶原蛋白结合后，DDR1 启动涉及 SRC 的信号级联并导致 MAP 激酶激活。这个复杂的网络通过基质金属蛋白酶 MMP2、MMP7 和 MMP9 的上调促进细胞外基质重塑，促进细胞迁移和伤口愈合，并促进肿瘤细胞侵袭。DDR1 的影响通过促进平滑肌细胞迁移延伸至动脉伤口愈合。此外，它使 PTPN11 磷酸化，对于怀孕期间正常囊胚植入、乳腺分化、哺乳以及维持正常耳朵形态和听力是不可或缺的。DDR1 的多功能作用强调了它在控制多种生理过程中的重要性。

Mouse

HEK293

C-hFc

Q03146-2 (M1-T414)

12305  [NCBI]

80-90 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.