2. Gene
  3. Ddr1 - discoidin domain receptor family, member 1 Gene

Ddr1 - discoidin domain receptor family, member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：盘状结构域受体家族，成员 1

种属: Mus musculus

同用名: Cak; Nep; PTK3A; CD167a; 6030432F18

基因 ID: 12305 | 基因类型: protein coding

关于 Ddr1

Chromosome 17: 35,992,459-36,015,513 reverse strand.GRCm39:CM001010.3

This gene has 12 transcripts (splice variants), 196 orthologues, 53 paralogues and is associated with 20 phenotypes. Ubiquitous expression in ovary adult (RPKM 32.9), colon adult (RPKM 31.1) and 24 other tissues.

功能概要

该基因编码的蛋白可启动胶原蛋白结合活性。参与多个过程，包括平滑肌细胞迁移；平滑肌细胞基质粘附；和伤口愈合，细胞扩散。作用于几个过程的上游或内部，包括胶原蛋白激活的酪氨酸激酶受体信号通路；乳腺发育；和神经元投射发育。位于质膜。以多种结构表达，包括中枢神经系统；未来的后脑；泌尿生殖系统；乳腺；和视网膜。该基因的人类直系同源物与肺非小细胞癌有关。与人类 DDR1（盘状蛋白结构域受体酪氨酸激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables collagen binding activity. Involved in several processes, including smooth muscle cell migration; smooth muscle cell-matrix adhesion; and wound healing, spreading of cells. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; mammary gland development; and neuron projection development. Located in plasma membrane. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; mammary gland; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human DDR1 (Discoidin Domain Receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ddr1 基因产物(4)

mRNA Protein Name
NM_007584.3 NP_031610.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_172962.1 NP_766550.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001198833.1 NP_001185762.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001198831.1 NP_001185760.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IDA
IDA: 通过直接分析推断
16806867 MGI
enables collagen binding IMP
IMP: 通过突变表型推断
12065315 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within axon development IMP
IMP: 通过突变表型推断
10970885 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
11283268 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
12397034 MGI
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway IDA
IDA: 通过直接分析推断
10970885 MGI
involved in collagen-activated tyrosine kinase receptor signaling pathway IMP
IMP: 通过突变表型推断
12065315 MGI
acts upstream of or within ear development IMP
IMP: 通过突变表型推断
11283268 MGI
acts upstream of or within embryo implantation IMP
IMP: 通过突变表型推断
11283268 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: 通过突变表型推断
11283268 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12397034 MGI
acts upstream of or within neuron projection extension IMP
IMP: 通过突变表型推断
10970885 MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation IDA
IDA: 通过直接分析推断
10970885 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
12397034 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
10970885 MGI
acts upstream of or within regulation of cell growth IMP
IMP: 通过突变表型推断
12397034 MGI
acts upstream of or within regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
12397034 MGI
involved in regulation of extracellular matrix disassembly IMP
IMP: 通过突变表型推断
12065315 MGI
involved in smooth muscle cell migration IMP
IMP: 通过突变表型推断
12065315 MGI
involved in smooth muscle cell-matrix adhesion IMP
IMP: 通过突变表型推断
12065315 MGI
involved in wound healing, spreading of cells IMP
IMP: 通过突变表型推断
12065315 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
12397034 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ddr1 蛋白结构

FA58C

FA58C: cd00057 (57 - 184)

PKc_like

PKc_like: cl21453 (601 - 904)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 911 a.a.
蛋白主名 其他名称

epithelial discoidin domain-containing receptor 1

CD167 antigen-like family member A

cell adhesion kinase

discoidin receptor tyrosine kinase

epithelial discoidin domain receptor 1

protein-tyrosine kinase MPK-6

tyrosine kinase DDR

tyrosine-protein kinase CAK

重组 Ddr1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75301 DDR1 Protein, Mouse (sf9, His-GST) Q03146-2 (L444-V874) ≥95%
HY-P75302 DDR1 Protein, Mouse (HEK293, His, solution) Q03146-2 (D20-T414) ≥95%
HY-P75303 DDR1 Protein, Mouse (HEK293, Fc) Q03146-2 (M1-T414) ≥95%
HY-P77639 DDR1 Protein, Mouse (HEK293, C-His) Q03146-2 (D20-A414) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-16961 Sitravatinib Inhibitor 99.57% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135401 VU6015929 Inhibitor 99.50% 否
HY-133670 DDR1-IN-6 Inhibitor 98.16% 否
HY-114173 DDR1-IN-4 Inhibitor 98.19% 否
HY-133669 DDR1-IN-5 Inhibitor 99.27% 否
HY-156552 DDR1/2 inhibitor-2 Inhibitor 99.73% 否
HY-167208 SR-302 Inhibitor / 否
HY-162102 DDR1-IN-8 Inhibitor / 否
HY-122848 DDR1/2 inhibitor-3 Inhibitor / 否
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ddr1 NCBI NCBI:780
Rattus norvegicus Ddr1 NCBI NCBI:25678
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