2. Gene
  3. DDR1 - discoidin domain receptor tyrosine kinase 1 Gene

DDR1 - discoidin domain receptor tyrosine kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：盘基蛋白结构域受体酪氨酸激酶 1

种属: Homo sapiens

同用名: CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A

基因 ID: 780 | 基因类型: protein coding

关于 DDR1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,880,970-30,900,156 (from NCBI)

This gene has 58 transcripts (splice variants), 1 gene allele, 196 orthologues and 53 paralogues. Ubiquitous expression in brain (RPKM 49.5), thyroid (RPKM 24.8) and 22 other tissues.

功能概要

受体酪氨酸激酶在细胞与其微环境的通讯中起着关键作用。这些激酶参与细胞生长、分化和代谢的调节。由该基因编码的蛋白质属于酪氨酸激酶受体的一个亚家族，在其细胞外结构域中与盘基网柄菌蛋白 discoidin I 具有同源性，并被各种类型的胶原蛋白激活。这种蛋白质的表达仅限于上皮细胞，特别是在肾、肺、胃肠道和脑中。此外，它已被证明在几种人类肿瘤中显着过度表达。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 2 月]

Receptor Tyrosine Kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

DDR1 基因产物(59)

mRNA Protein Name
NM_001387911.1 NP_001374840.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
XM_011514884.2 XP_011513186.1 epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387916.1 NP_001374845.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001297653.2 NP_001284582.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_013994.3 NP_054700.2 epithelial discoidin domain-containing receptor 1 isoform 3 precursor
XM_017011268.3 XP_016866757.1 epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387912.1 NP_001374841.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387900.1 NP_001374829.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419318.1 XP_047275274.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419327.1 XP_047275283.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_024446541.2 XP_024302309.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419324.1 XP_047275280.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419330.1 XP_047275286.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419332.1 XP_047275288.1 epithelial discoidin domain-containing receptor 1 isoform X4
NM_001387909.1 NP_001374838.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387892.1 NP_001374821.1 epithelial discoidin domain-containing receptor 1 isoform 3 precursor
NM_001202523.3 NP_001189452.2 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
XM_047419323.1 XP_047275279.1 epithelial discoidin domain-containing receptor 1 isoform X1
NM_013993.3 NP_054699.2 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387901.1 NP_001374830.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001202521.1 NP_001189450.1 epithelial discoidin domain-containing receptor 1 isoform 4 precursor
NM_001387904.1 NP_001374833.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419331.1 XP_047275287.1 epithelial discoidin domain-containing receptor 1 isoform X3
XM_047419326.1 XP_047275282.1 epithelial discoidin domain-containing receptor 1 isoform X2
XM_047419333.1 XP_047275289.1 epithelial discoidin domain-containing receptor 1 isoform X4
XM_047419322.1 XP_047275278.1 epithelial discoidin domain-containing receptor 1 isoform X1
NM_001387913.1 NP_001374842.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387915.1 NP_001374844.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387894.1 NP_001374823.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001297654.2 NP_001284583.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419328.1 XP_047275284.1 epithelial discoidin domain-containing receptor 1 isoform X5
NM_001954.5 NP_001945.3 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387906.1 NP_001374835.1 epithelial discoidin domain-containing receptor 1 isoform 7 precursor
NM_001297652.2 NP_001284581.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387918.1 NP_001374847.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387897.1 NP_001374826.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001202522.1 NP_001189451.1 epithelial discoidin domain-containing receptor 1 isoform 5 precursor
NM_001387893.1 NP_001374822.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387910.1 NP_001374839.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387902.1 NP_001374831.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419329.1 XP_047275285.1 epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419319.1 XP_047275275.1 epithelial discoidin domain-containing receptor 1 isoform X1
NM_001387899.1 NP_001374828.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419320.1 XP_047275276.1 epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419334.1 XP_047275290.1 epithelial discoidin domain-containing receptor 1 isoform X4
NM_001387898.1 NP_001374827.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419325.1 XP_047275281.1 epithelial discoidin domain-containing receptor 1 isoform X2
NM_001387895.1 NP_001374824.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387914.1 NP_001374843.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387908.1 NP_001374837.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
XM_024446540.2 XP_024302308.1 epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387903.1 NP_001374832.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419321.1 XP_047275277.1 epithelial discoidin domain-containing receptor 1 isoform X1
NM_001410869.1 NP_001397798.1 epithelial discoidin domain-containing receptor 1 isoform 6 precursor
XM_011514887.3 XP_011513189.1 epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387896.1 NP_001374825.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387917.1 NP_001374846.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387905.1 NP_001374834.1 epithelial discoidin domain-containing receptor 1 isoform 7 precursor
NM_001387907.1 NP_001374836.1 epithelial discoidin domain-containing receptor 1 isoform 7 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IDA
IDA: 通过直接分析推断
9659899 GOA
enables collagen binding IMP
IMP: 通过突变表型推断
12065315 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16337946 GOA
enables protein tyrosine kinase collagen receptor activity IDA
IDA: 通过直接分析推断
9659899 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in collagen-activated tyrosine kinase receptor signaling pathway IDA
IDA: 通过直接分析推断
9659899 GOA
involved in collagen-activated tyrosine kinase receptor signaling pathway IMP
IMP: 通过突变表型推断
12065315 GOA
involved in peptidyl-tyrosine autophosphorylation IDA
IDA: 通过直接分析推断
21044884 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
9659899 GOA
involved in regulation of extracellular matrix disassembly IMP
IMP: 通过突变表型推断
12065315 GOA
involved in smooth muscle cell migration IMP
IMP: 通过突变表型推断
12065315 GOA
involved in smooth muscle cell-matrix adhesion IMP
IMP: 通过突变表型推断
12065315 GOA
involved in wound healing, spreading of cells IMP
IMP: 通过突变表型推断
12065315 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDR1 蛋白结构

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (47 - 182)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (610 - 905)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 913 a.a.
蛋白主名 其他名称

epithelial discoidin domain-containing receptor 1

CD167 antigen-like family member A

PTK3A protein tyrosine kinase 3A

cell adhesion kinase

mammary carcinoma kinase 10

neuroepithelial tyrosine kinase

neurotrophic tyrosine kinase, receptor, type 4

protein-tyrosine kinase RTK-6

tyrosine kinase DDR

tyrosine-protein kinase CAK

DDR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DDR1 Q08345 DDR2 Homo sapiens Q16832
Anti Tag CoIP
33961781
种属内
DDR1 Q08345 PTPN11 Homo sapiens Q06124
Anti Tag CoIP
16337946
种属内
DDR1 Q08345 PTPN11 Homo sapiens Q06124
Anti Bait CoIP
16337946
种属内
DDR1 Q08345 NCK2 Homo sapiens O43639
Anti Tag CoIP
16337946
种属内
DDR1 Q08345 NCK2 Homo sapiens O43639
Pull Down
16337946
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DDR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75304 DDR1 Protein, Human (sf9, His-GST) Q08345 (R444-V913) ≥95%
HY-P75305 DDR1 Protein, Human (HEK293, His) Q08345 (D19-T416) ≥95%

关联疾病

疾病名称 别名
Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Degeneration

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Cervix Small Cell Carcinoma

Small Cell Carcinoma Of The Cervix

Small Cell Carcinoma Of The Cervix Uteri
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome

Smed-Sl

Smed-Sl/Ac

Smed Short Limb-Abnormal Calcification Type

Smed Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia Short Limb-Hand Type

Smed, Type Ii

Smed Type 2

Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type

Smed, Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type

Smed, Short Limb-Abnormal Calcification Type

Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification

Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type

SEMD-SL

Smed Type Ii

Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Mast-Cell Leukemia

Mast Cell Leukemia

Leukemia, Mast-Cell

Leukemia Mast Cell

Mast Cell Leukaemia Nos

Mast Cell Leukaemia Without Mention Of Remission
Alport Syndrome

Hereditary Nephritis

Alport Syndrome, X-Linked

Hemorrhagic Hereditary Nephritis

Congenital Hereditary Hematuria

Hemorrhagic Familial Nephritis

Familial Nephritis

Thin Basement Membrane Disease

Thin Basement Membrane Nephropathy

Hematuria-Nephropathy-Deafness Syndrome

Hematuric Hereditary Nephritis

Hereditary Familial Congenital Hemorrhagic Nephritis

Hereditary Hematuria Syndrome

Hereditary Interstitial Pyelonephritis

Alport Deafness-Nephropathy

Alport Hearing Loss-Nephropathy

Alports Syndrome

Nephritis, Hereditary
Pulmonary Fibrosis

Fibrosis Of Lung
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-16961 Sitravatinib Inhibitor 99.57% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135401 VU6015929 Inhibitor 99.50% 否
HY-133670 DDR1-IN-6 Inhibitor 98.16% 否
HY-114173 DDR1-IN-4 Inhibitor 98.19% 否
HY-133669 DDR1-IN-5 Inhibitor 99.27% 否
HY-156552 DDR1/2 inhibitor-2 Inhibitor 99.73% 否
HY-162102 DDR1-IN-8 Inhibitor / 否
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DDR1 RGD RGD:2252
Macaca mulatta DDR1 VGNC VGNC:81058
Mus musculus DDR1 MGD MGI:99216
Bos taurus DDR1 VGNC VGNC:53966
Felis catus DDR1 VGNC VGNC:102411
Canis familiaris DDR1 VGNC VGNC:57221
Others DDR1 NCBI
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