EDA2R/XEDAR 蛋白, Mouse (HEK293, His)

The EDA2R/XEDAR protein is a receptor for EDA isoform A2 (but not A1) and plays a key role in activating the NF-kappa-B and JNK pathways. This activation involves binding to TRAF3 and TRAF6, as indicated by protein similarity. EDA2R/XEDAR Protein, Mouse (HEK293, His) is the recombinant mouse-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EDA2R/XEDAR Protein, Mouse (HEK293, His) is 138 a.a..

EDA2R/XEDAR 蛋白被鉴定为 EDA 同工型 A2（但不是 A1）的受体，在介导 NF-kappa-B 和 JNK 通路的激活中发挥着关键作用。正如与相关蛋白的相似性所表明的，激活过程似乎涉及 EDA2R/XEDAR 与 TRAF3 和 TRAF6 的结合。此外，EDA2R/XEDAR 与 TRAF1、TRAF3 和 TRAF6 相关，进一步表明其参与与免疫和炎症反应相关的信号通路。复杂的相互作用和激活机制强调了 EDA2R/XEDAR 在细胞信号级联中的重要性，对各种生理过程和细胞反应具有潜在影响。

Immobilized Mouse EDA2R at 0.1 μg/mL (100 μL/well) can bind Recombinant Human EDA‑A2. The ED₅₀ for this effect is 9.596 ng/mL.

Mouse

HEK293

C-6*His

Q8BX35 (M1-T138)

245527  [NCBI]

MDCQENEYRDQWGRCVTCQQCGPGQELSKDCGYGEGGDAHCIVCPPRKYKSTWGHHRCQTCITCAVINRVQKANCTNTSNAICGDCLPRFYRKTRIGGLQDQECIPCTKQTPSSEVQCTFQLSLVKVDAHTVPPREAT

Approximately 26-29 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 6.5, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.